阿托伐他汀辅助治疗在老年急性脑梗死中的效果及对血脂水平的影响研究

Study on the Efficacy and Blood Lipid Levels of Atorvastatin Adjuvant Therapy in Elderly Patients with Acute Cerebral Infarction

目的 评价阿托伐他汀辅助治疗老年急性脑梗死患者的效果及对血脂水平的影响。方法 回顾性选取2021年11月—2023年10月上海中冶医院神经内科收治的68例老年急性脑梗死患者的临床资料,依据治疗方法的不同分为两组,每组34例。对照组予以常规治疗,观察组在对照组基础上予以阿托伐他汀钙治疗,比较两组患者临床疗效、血脂水平、功能恢复指标。结果 观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。治疗后,观察组甘油三酯为(1.01±0.23)mmol/L、总胆固醇为(3.06±0.31)mmol/L、低密度脂蛋白胆固醇为(2.16±0.39)mmol/L均低于对照组的(1.44±0.37)mmol/L、(4.85±0.57)mmol/L、(3.89±0.48)mmol/L,高密度脂蛋白胆固醇为(1.91±0.72)mmol/L高于对照组的(1.33±0.55)mmol/L,差异有统计学意义(t=5.755、16.086、16.311、3.797,P均<0.001)。治疗后,观察组神经功能评分低于对照组,日常生活能力高于对照组,差异有统计学意义(P均<0.05)。结论 老年急性脑梗死患者采取阿托伐他汀辅助治疗效果显著,可良好改善血脂水平,促进患者神经、生活能力的恢复。

Objective To evaluate the efficacy and blood lipid levels of atorvastatin adjuvant therapy in the treatment of elderly acute cerebral infarction.Methods The clinical data of 68 elderly patients with acute cerebral infarction admitted to the Department of Neurology of Shanghai Zhongye Hospital from November 2021 to October 2023 were retrospectively selected and divided into two groups according to different treatment methods,with 34 cases in each group.The control group was given conventional treatment,and the observation group was treated with atorvastatin calcium on the basis of the control group.The clinical efficacy,blood lipid level and functional recovery indexes of the two groups were compared.Results The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).After treatment,The triglyceride(1.01±0.23)mmol/L,total cholesterol(3.06±0.31)mmol/L and low density lipoprotein cholesterol(2.16±0.39)mmol/L in the observation group were lower than those in the control group(1.44±0.37)mmol/L,(4.85±0.57)mmol/L and(3.89±0.48)mmol/L,high density lipoprotein cholesterol(1.91±0.72)mmol/L was higher than that of control group(1.33±0.55)mmol/L,the differences were statistically significant(t=5.755,16.086,16.311,3.797,all P<0.001).After treatment,the neurological function score of the observation group was lower than that of the control group,and the ability of daily living was higher than that of the control group,the differences were statistically significant(both P<0.05).Conclusion The effect of atorvastatin adjuvant therapy in elderly patients with acute cerebral infarction is remarkable,which can improve blood lipid level and promote the recovery of nerve and life ability of patients.