格列美脲+二甲双胍在老年糖尿病患者中的应用效果及对FPG、2 hPG、HbA1c水平影响分析

Application Effect of Glimepiride and Metformin in Elderly Patients with Diabetes Mellitus and Its Impact on FPG,2 hPG and HbA1c Levels

目的 研讨格列美脲+二甲双胍在老年糖尿病患者中的应用效果及对空腹血糖(fasting plasma glucose,FPG)、餐后2 h血糖(2-hour postprandial plasma glucose, 2 hPG)以及糖化血红蛋白(glycosylated hemoglobin A1c, HbA1c)水平的影响。方法 单纯随机选取2021年2月—2024年2月福建省泉州市永春县医院收治的100例老年糖尿病患者为研究对象,根据不同用药方案分为对照组和观察组,每组50例。对照组单服二甲双胍,观察组予以格列美脲+二甲双胍用药,比较两组患者方案疗效、糖脂指标、胰岛功能以及方案安全性。结果观察组治疗总有效率为96.00%(48/50),高于对照组的82.00%(41/50),差异有统计学意义(χ^(2)=5.005,P=0.025)。治疗后,观察组FPG、2 hPG、HbA1c及三酰甘油水平均低于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组空腹胰岛素、胰岛素分泌指数均高于对照组,差异有统计学意义(P均<0.05)。两组患者用药不良反应总发生率比较,差异无统计学意义(P>0.05)。结论 对老年糖尿病患者施以格列美脲+二甲双胍方案用药可明显提升疗效,更有效改善患者的糖脂指标及胰岛功能,并且保障用药安全。

Objective To investigate the effect of glimepiride plus metformin on fasting plasma glucose(FPG),2-hour postprandial plasma glucose(2 hPG)and glycosylated hemoglobin A1c(HbA1c)in elderly patients with diabetes mellitus.Methods A total of 100 elderly patients diagnosed with diabetes admitted to Yongchun County Hospital of Quanzhou City in Fujian Province from February 2021 to February 2024 were simply and randomly selected as the research objects,according to different medication regimens,they were divided into control group and observation group,with 50 cases in each group.The control group was treated with metformin alone,and the observation group was treated with glimepiride+metformin.The efficacy,glycolipid index,islet function and safety of the two groups were compared.Results The total effective rate of treatment in the observation group was 96.00%(48/50),which was higher than 82.00%(41/50)in the control group,and the difference was statistically significant(χ^(2)=5.005,P=0.025).After treatment,levels of FPG,2 hPG,HbA1c and triglyceride in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).After treatment,the fasting insulin and insulin secretion index in the observation group were higher than those in the control group,and the differences were statistically significant(all P<0.05).There was no significant difference in the incidence of adverse drug reactions between patients in two groups(P>0.05).Conclusion the application of glimepiride+metformin in elderly patients with diabetes can significantly improve the curative effect,more effectively improve the patients'glucose and lipid indicators and islet function,and ensure the safety of medication.