乳腺癌化疗所致周围神经病变患者运动干预的范围综述

Scoping review of exercise interventions for chemotherapy-induced peripheral neuropathy in breast cancer patients

目的对乳腺癌化疗所致周围神经病变运动干预的相关研究进行范围综述,为开展运动干预提供参考。方法基于JBI范围综述框架,系统检索国内外常用数据库,检索时限为建库至2024年3月31日,对检索出的文献进行筛选和信息提取。结果共纳入13篇文献,其中10篇随机对照试验,3篇类实验研究。运动类型包括有氧运动、抗阻运动、感觉运动训练、平衡训练、振动训练、神经舞蹈训练、自行设计的四肢锻炼操等;总干预时长4~12周或化疗时长,运动强度多为轻中度,运动频率多为2~5次/周,30~60 min/次。运动干预评价指标包括安全性、依从性、化疗所致周围神经病变症状及其严重程度、生活质量等。结论运动干预可改善乳腺癌患者化疗所致周围神经病变发生率及严重程度、提高患者生活质量,但运动干预策略和评价标准存在较大差异,有待更多证据以制订最佳运动干预方案。

ion was performed by two reviewers and verified by a third reviewer.Results Thirteen articles were included,of which 10 were randomized controlled trials and 3 were quasi-experimental studies.The types of exercise included aerobic exercise,resistance training,sensorimotor exercise,balance training,vibration training,neurologic dance training,and self-designed extremity exercise.The intervention program lasted 4-12 weeks or throug-hout chemotherapy.The intensity of exercise was mild to moderate,with a frequency of 2-5 times per week and 30-60 minutes per time.Evaluation indexes included safety,adherence,symptoms and severity of CIPN,and quality of life.Conclusion Exercise intervention can reduce incidence and severity of CIPN in breast cancer patients and enhance their quality of life.However,the specific strategies and evaluation criteria are quite different in these studies.More evidence is needed to develop the best exercise intervention program.