新型冠状病毒感染患者潜在的胃肠道症状与心理健康状况相关性研究

Potential gastrointestinal symptoms after coronavirus disease 2019 are associated with mental health status

目的 探讨新型冠状病毒感染(COVID-19)患者出现的慢性胃肠道症状与焦虑和抑郁等心理健康状况的相关性。方法 设计一组有关胃肠道症状及心理健康问题的调查问卷,于2023年7月1日至2023年9月1日对326名在海军军医大学第一附属医院消化内科门诊就诊的有COVID-19病史的患者进行随机调查。结果 从调查问卷的平均得分来看,患者在感染期间和感染后均表现出躯体症状(PHQ-15=5~9分)和健康焦虑(SHAI>15分)状态,有胃肠道疾病史(P<0.05)和健康焦虑(P<0.001)的患者胃肠道症状发生更加频繁。患者感染期间的躯体状况及胃肠道症状更差(P=0.003),抑郁症状更严重(P=0.004),在感染期间感到不适和在感染之后出现胃肠道症状的患者更有可能出现焦虑症状。结论 COVID-19能增加胃肠道症状的发生频率和抑郁的发生,健康焦虑对胃肠道症状的发生有影响,这为认知行为疗法可能对胃肠门诊患者有益提供证据,并为消化道疾病的治疗提供了新的视角。

Objective To assess the possible correlations between chronic gastrointestinal symptoms(GISs)and mental health status(anxiety,depression,etc)after coronavirus disease 2019(COVID-19).Methods A random survey related to GISs and mental health status was performed in 326 gastrointestinal outpatients with a history of COVID-19 in Department of Gastroenterology,The First Affiliated Hospital of Naval Medical University from July 1,2023 to September 1,2023.Results Deriving from mean scores of the survey questionnaire,participants as a whole presented a state of somatic problems(PHQ-15=5-9)and health anxiety(SHAI>15)during and after COVID-19.History of gastrointestinal diseases(P<0.05)and health anxiety(P<0.001)were associated with the GISs frequency.Somatic symptoms,especially GISs,presented more frequently(P=0.003)and people were more likely to show signs of depression(P=0.004)during COVID-19.The outpatients who felt sick during COVID-19 and had GISs after COVID-19 were more likely to show anxiety symptoms.Conclusion COVID-19 aggravates the presence of GISs and depression.Anxiety has a significant influence on the frequency of GISs,which provides evidence that cognitive-behavioral therapy may be beneficial for gastrointestinal outpatients and offers a new perspective for the treatment of digestive diseases.