应用丙种球蛋白冲击治疗老年重症社区获得性肺炎患者的临床有效性评估

Clinical Efficacy Evaluation of Using Immunoglobulin Shock Therapy in Elderly Patients with Severe Community-acquired Pneumonia

目的 探讨老年重症社区获得性肺炎治疗中应用丙种球蛋白冲击疗法的成效。方法 非随机选取2022年9月-2023年12月济南市民族医院收治的86例老年重症社区获得性肺炎患者为研究对象。按治疗方法分为两组,每组43例。参照组采取常规治疗方案,研究组采用常规治疗联合应用丙种球蛋白冲击疗法。比较两组免疫功能指标水平、降钙素原水平、不良反应发生率。结果 治疗后,研究组免疫功能指标优于参照组,差异有统计学意义(P均<0.05)。研究组降钙素原水平为(0.50±0.14)μg/L,低于参照组的(0.79±0.16)μg/L,差异有统计学意义(t=8.945,P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 丙种球蛋白冲击疗法治疗老年重症社区获得性肺炎科可善免疫功能指标,减轻炎症反应。

Objective To explore the effectiveness of using immunoglobulin shock therapy in the treatment of severe community-acquired pneumonia in the elderly.Methods Eighty-six cases of elderly patients with severe community-acquired pneumonia admitted to Jinan Ethnic Hospital from September 2022 to December 2023 were non-randomly selected as study subjects.They were divided into two groups according to treatment methods,with 43 cases in each group.The reference group adopted conventional treatment program,and the research group used conventional treat-ment combined with the application of gammaglobulin shock therapy.The levels of immune function indexes,calcito-ninogen levels,and the incidence of adverse reactions were compared between the two groups.Results After treat-ment,the immune function indexes of the study group were better than those of the reference group,and the differ-ences were statistically significant(all P<0.05).The calcitoninogen level of the study group was(0.50±0.14)µg/L,lower than(0.79±0.16)µg/L of the reference group,and the difference was statistically significant(t=8.945,P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Gammaglobulin shock therapy for the treatment of severe community-acquired pneumonia in the elderly Section improves immune function indicators and reduces the inflammatory response.