基于气机升降理论的中医三联疗法治疗心肾不交型不寐的临床研究

Clinical study on TCM triple therapy in treating heart kidney disharmony type insomnia based on theory of ascending and descending movement of qi

目的评价基于气机升降理论的中医三联疗法治疗心肾不交型不寐患者的临床效果。方法选择2021年1-12月该院收治确诊的68例心肾不交型不寐患者为研究对象,随机分为治疗组和对照组,每组34例。治疗组采用中药内服+头部循经刮痧+引阳入阴气息引导推拿的中医三联法治疗;对照组采用口服艾司唑仑片治疗。比较两组疗效、睡眠质量[匹兹堡睡眠质量指数(PSQI)评分]、中医症候积分及神经递质[5-羟色胺(5-HT)、多巴胺(DA)]水平。结果治疗3周后,治疗组总有效率及5-HT水平均明显高于对照组(P<0.05),PSQI总评分、中医症候积分、DA水平均明显低于对照组(P<0.05)。结论中医三联疗法治疗心肾不交型不寐可显著改善患者的临床症状、神经递质水平,提高患者睡眠质量,值得推广应用。

Objective To evaluate the clinical effect of Traditional Chinese Medcine(TCM)triple therapy based on the theory of ascending and descending movement of qi in the treatment of heart kidney disharmony type insomnia.Methods Sixty-eight patients with heart-kidney disharmony type insomnia treated in this hospital from January to December 2021 were selected as the research subjects and randomly divided into the treatment group and control group,34 cases in each group.The treatment group adopted TCM oral administration+head scraping along the meridians+breathe Yang into Yin to guide massage;the control group orally took estazolam tablets.The efficacy,sleep quality[Pittsburgh Sleep Quality Index(PSQI)score],traditional Chinese medicine syndrome score,and neurotransmitter[5-hydroxytryptamine(5-HT),dopamine(DA)]levels were compared between the two groups.Results After 3 weeks of treatment,the total effective rate and 5-HT level of the treatment group were significantly higher than those of the control group(P<0.05);the PSQI score,TCM symptom score and DA level in the treatment group were significantly lower than those in the control group(P<0.05).Conclusion The TCM triple therapy could significantly improve the clinical symptoms,neurotransmitter level and sleep quality in the patients with heart-kidney disharmony type insomnia.The therapy is worthy of application and promotion.