哌甲酯联合脑电生物反馈训练对儿童边缘智力合并多动症患儿脑电图及适应行为的影响

Effects of methylphenidate combined with electroencephalographic biofeedback training on electroencephalogram and adaptive behaviors of children patients with children borderline intelligence complicating attention-deficit hyperactivity disorder

目的探讨哌甲酯联合脑电生物反馈(EEG-B)训练对儿童边缘智力(BIF)合并多动症患儿脑电图及适应行为的影响。方法选择2021年6月至2023年5月该院收治的84例BIF合并多动症患儿作为研究对象,并按随机数字表法分成药物组(应用哌甲酯治疗)和联合组(在药物组基础上联合EEG-B训练),每组42例。比较两组病情状况[采用注意缺陷多动障碍筛查量表(SNAP-Ⅳ)-父母版评定]、脑电波频率[β波、θ波、感觉运动节律(SMR)波]、血清神经递质水平[5-羟色胺(5-HT)、多巴胺(DA)]及适应行为[采用儿童适应行为评定量表(CABR)评定]。结果治疗12周后,两组SNAP-Ⅳ中的注意力缺陷、多动/冲动评分及θ波频率均低于治疗前(P<0.05),且联合组均低于药物组(P<0.05)。治疗12周后,两组β波、SMR波频率和血清5-HT、DA水平及CABR中的独立功能、认知功能和社会自制评分均高于治疗前(P<0.05),且联合组均高于药物组(P<0.05)。结论对BIF合并多动症患儿应用哌甲酯联合EEG-B训练干预,可有效调节患儿血清神经递质水平,明显改善脑电波频率及病情,显著提高适应行为水平。

Objective To explore the effects of methylphenidate combined with electroencephalographic biofeedback(EEG-B)training on the electroencephalogram and adaptive behaviors of children patients with children borderline intellectual functioning(BIF)complicating attention-deficit hyperactivity disorder(ADHD).Methods Eighty-four children patients with BIF complicating ADHD admitted and treated in this hospital from June 2021 to May 2023 were selected as the research subjects and divided into the drug group(treated with methylphenidate)and combination group(combining with EEG-B training on the basis of the drug group)according to the random number table method,42 cases in each group.The disease condition[adopting the Attention Deficit Hyperactivity Disorder Screening Scale(SNAP-Ⅳ)-Parent Version Assessment],brainwave frequencies[βwave,θwave,sensorimotor rhythms(SMR)waves],serum neurotransmitter levels[5-hydroxytryptamine(5-HT),dopamine(DA)]and adaptive behaviors[adopting the Children′s Adaptive Behavior Rating Scale(CABR)]were compared between the two groups.Results After 12-week treatment,the attention deficit,hyperactivity/impulsivity scores of SNAP-Ⅳandθwaves frequency in both groups were lower than those before treatment(P<0.05),which in the combination group were lower than the drug group(P<0.05).After 12-week treatment,βwaves frequency,SMR waves frequency,and the levels of serum 5-HT,DA,and the independent function,cognitive function and social self-made scores in CABR in both groups were higher than those before treatment(P<0.05),which in the combination group were higher than the drug group(P<0.05).Conclusion The application of methylphenidate combined with EEG-B training intervention in the children patients with BIF complicating ADHD could effectively regulate the serum neurotransmitter levels,significantly improve the frequency of brain waves and disease condition and increase the level of adaptive behavior.