α-干扰素治疗慢性乙型肝炎对患者肝功能、乙型肝炎表面抗原及甲状腺功能的影响

Effect ofα-interferon in treating chronic hepatitis B on liver function,hepatitis B surface antigen and thyroid function

目的探讨α-干扰素治疗慢性乙型肝炎对患者肝功能、乙型肝炎表面抗原(HBsAg)及甲状腺功能的影响。方法选取2019年1月1日至2022年7月31日在该院诊治的符合纳入标准的130例慢性乙型肝炎患者进行分析。所有患者均给予聚乙二醇干扰素α-2b治疗,根据治疗后是否发生病毒学应答分为应答组、无应答组。比较两组血常规、肝功能指标、HBsAg、乙型肝炎e抗原(HBeAg)、乙型肝炎病毒DNA(HBV-DNA)及甲状腺功能的变化。结果应答组60例,无应答组70例。治疗后,应答组ALT水平明显低于无应答组(P<0.05),两组血清AST、总胆红素水平比较,差异均无统计学意义(P>0.05)。治疗后,应答组患者HBsAg、HBeAg、HBV-DNA水平明显低于无应答组(P<0.05)。治疗后,应答组促甲状腺激素(TSH)水平明显低于未应答组(P<0.05),总三碘甲状腺氨酸(TT3)、总甲状腺素(TT4)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)水平明显高于未应答组(P<0.05)。治疗后,应答组患者甲状腺疾病总发生率为8.33%,无应答组甲状腺疾病总发生率为27.14%,两组比较,差异有统计学意义(P<0.05)。结论接受α-干扰素治疗并发生病毒学应答的慢性乙型肝炎患者临床效果显著,可明显改善患者肝功能,加快机体内乙型肝炎病毒的转阴速度,其中甲状腺功能改变是患者使用α-干扰素治疗过程中的常见不良反应,需监测甲状腺功能相关指标,对甲状腺功能异常的积极治疗可保证α-干扰素治疗的效果。

Objective To explore the effects ofα-interferon in treating chronic hepatitis B on the liver function,hepatitis B surface antigen(HBsAg)and thyroid function.Methods A total of 130 patients with chronic hepatitis B meeting the inclusion criteria and treated in this hospital from January 1,2019 to July 31,2022 were selected for analysis.All patients were treated with pegylated interferonα-2b and divided into the response group and non-response group based on whether or not the virological response occurring after treatment.The changes of blood routine,liver function indicators,HBsAg,hepatitis B virus e antigen(HBeAg),hepatitis B virus DNA(HBV-DNA)and thyroid function were compared between two groups.Results There were 60 cases in the response group and 70 cases in the non-response group.After treatment,the ALT level in the response group was significantly lower than that in the non-response group(P<0.05),and there was no statistically significant difference in serum AST and total bilirubin levels between the two groups(P>0.05).After treatment,the levels of HBsAg,HBeAg and HBV-DNA in the response group were significantly lower than those in the non-response group(P<0.05).After treatment,the level of thyroid stimulating hormone(TSH)in the response group was significantly lower than that in the non-response group(P<0.05),while the levels of total triiodothyronine(TT3),total thyroxine(TT4),free triiodothyronine(FT3),and free thyroxine(FT4)were significantly higher than those in the non-response group(P<0.05).After treatment,the total incidence rate of thyroid disease in the response group was 8.33%,while which in the non-response group was 27.14%,and the difference between the two groups was statistically significant(P<0.05).Conclusion The clinical effect of the patients with chronic hepatitis B receivingα-interferon treatment and experiencing virological response is remarkable,which can significantly improve the patients′liver function,accelerate the rate of negative conversion of hepatitis B virus in the body,in which the alteration of the thyroid function is a common adverse reaction during the process ofα-interferon treatment,and it is necessary to monitor the relevant indexes of the thyroid function,and the active treatment of thyroid function abnormality could ensure the effect ofα-interferon therapy.