SiewertⅢ型食管胃结合部腺癌的分子生物学研究进展

Research advances in molecular biology of Siewert typeⅢadenocarcinoma of esophagogastric junction

目前食管胃结合部腺癌(AEG)的发病率在全球范围内呈上升趋势。随着分子生物学技术的不断发展,越来越多的分子标志物及发病机制被发现,为AEG的诊断与治疗提供了新思路。该文主要就SiewertⅢ型AEG的细胞起源、常见突变基因、基因亚型、异常非编码RNA及异常传导通路等分子生物学研究进行综述,为AEG的研究现状提供一些参考,丰富了非编码RNA及信号通路的内容,为针对异常基因的靶向治疗提供了理论依据。目前的相关研究揭示了AEG的分子改变特征,但是未对基因互作、信号通路深层调控机制进行研究,未来还需联合多组学分析进行深入研究,推动AEG的精准发展。

At present,the incidence rate of adenocarcinoma at esophagogastric junction(AEG)is on the rise all over the world.With the continuous development of molecular biology technology,more and more molecular markers and pathogenesis have been found,providing new ideas for the diagnosis and treatment of AEG.This article mainly reviews the molecular biology research on the cell origin,common mutated genes,gene subtypes,abnormal non-coding RNA and abnormal transmission pathways of SiewertⅢAEG,providing some reference for the current research status of AEG,enriching the content of non-coding RNA and signal pathways,and providing a theoretical basis for targeted treatment of abnormal genes.Current research has revealed the molecular changes in AEG,but did not investigate the deep regulatory mechanisms of gene interactions and signaling pathways.In the future,further in-depth research is needed in conjunction with multi-omics analysis to promote the precise development of AEG.