慢性阻塞性肺疾病合并肺癌的发病机制与治疗研究进展

Research advances in pathogenesis and treatment of chronic obstructive pulmonary disease complicating lung cancer

慢性阻塞性肺疾病(COPD)和肺癌均好发于吸烟人群和中老年人,是全球范围内具有高发病率、高病死率的两大呼吸系统疾病。COPD患者具有更高的肺癌罹患风险,COPD合并肺癌在临床上常见。该文综述了COPD与肺癌之间发病机制的关联、治疗原则,并重点讨论了现有的各类肺癌治疗策略在COPD合并肺癌人群中的疗效差异。尽管对COPD合并肺癌发病机制的研究日渐丰富,COPD与肺癌的治疗手段亦有长足进展,但COPD合并肺癌患者往往预后更差,仍存在治疗困境,其个体化、精准化的治疗策略有待探索。进一步揭示COPD合并肺癌新的发病机制,探索可能的疗效预测标记物和新的治疗靶点,是丰富COPD合并肺癌患者个体化治疗策略、改善预后的重要研究方向。

Chronic obstructive pulmonary disease(COPD)and lung cancer are most common in smoking population and middle-aged and elderly people,and are the two major respiratory diseases with high incidence and high mortality in the world.The patients with COPD have a higher risk of lung cancer,and COPD complicating lung cancer is common in clinic.This article reviews the asscociation of pathogenesis of COPD and lung cancer,treatment principles,and focus on the effects difference of various existing lung cancer treatment strategies in the patients with COPD complicating lung cancer.Although the research on the pathogenesis of COPD complicating lung cancer is increasingly abundant,and the treatment of COPD and lung cancer has made great progress,but the prognosis of COPD complicating lung cancer is often worse,and the treatment dilemmas still exist.The individualized and precise treatment strategies need to be explored.Further revealing the new pathogenesis of COPD complicating lung cancer,exploring possible predictive markers of efficacy and new therapeutic targets are the important research directions for enriching the individualized treatment strategies and improving the prognosis of the patients with COPD complicating lung cancer.