养正透邪祛毒法联合NAC方案化疗对三阴性乳腺癌患者疗效、T细胞亚群及癌因性疲乏的影响

Effects of Yangzheng Touxie Qudu Method Combined with NAC Regimen Chemotherapy on Efficacy,T Cell Subsets and Cancer-Related Fatigue in Patients with Triple Negative Breast Cancer

目的:探讨养正透邪祛毒法联合NAC方案(多西他赛+表柔比星+环磷酰胺)化疗对三阴性乳腺癌患者疗效、T细胞亚群及癌因性疲乏的影响。方法:选取2022年6月至2023年6月该院诊治的三阴性乳腺癌患者100例,根据随机数字表法分为对照组和观察组,各50例。对照组患者给予NAC方案治疗,观察组患者给予口服自拟养正透邪祛毒方与NAC方案联合治疗。观察两组患者的疗效、T淋巴亚群、炎症因子、癌因性疲乏水平及不良反应发生情况。结果:观察组患者的总有效率为82.00%(41/50),明显高于对照组的58.00%(29/50),差异有统计学意义(P<0.05)。治疗后,两组患者CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)、白细胞介素(IL)12和IL-2水平均较治疗前升高,且观察组患者较对照组更高;两组患者CD8^(+)、肿瘤坏死因子α和可溶性白细胞介素-2受体水平,躯体、认知和情感疲乏评分均较治疗前降低,且观察组患者较对照组更低,上述差异均有统计学意义(P<0.05)。观察组、对照组患者的不良反应发生率分别为24.00%(12/50)、28.00%(14/50),差异无统计学意义(P>0.05)。结论:养正透邪祛毒法与NAC方案化疗联合治疗三阴性乳腺癌患者,可明显提高疗效,改善T细胞亚群水平,降低炎症反应,改善癌因性疲乏状况,安全性佳。

OBJECTIVE:To probe into the effects of Yangzheng Touxie Qudu method combined with NAC regimen(docetaxel+epirubicin+cyclophosphamide)chemotherapy on efficacy,T cell subsets and cancer-related fatigue in patients with triple negative breast cancer.METHODS:From Jun.2022 to Jun.2023,totally 100 cases of triple negative breast cancer diagnosed and treated in the hospital were extracted to be divided into the control group and observation group according to the random number table method,with 50 cases in each group.The control group was treated with NAC regimen,while the observation group received self formulated Yangzheng Touxie Qudu formula combined with NAC regimen.The efficacy,T-lymphocyte subsets,inflammatory factors,cancer-related fatigue levels,and incidence of adverse drug reactions of two groups were observed.RESULTS:The total effective rate of observation group was 82.00%(41/50),significantly higher than that 58.00%(29/50)of control group,the difference was statistically significant(P<0.05).Compared with before treatment,CD3^(+),CD4^(+),CD4^(+)/CD8^(+),interleukin(IL)-12 and IL-2 levels increased significantly in both groups after treatment,and the observation group was higher than the control group;compared with before treatment,CD8^(+),tumor necrosis factor-α,soluble interleukin-2 receptor levels,physical,cognitive and emotional fatigue scores decreased in both groups after treatment,and the observation group was lower than the control group,with statistically significant differences(P<0.05).The incidence of adverse drug reactions in observation group and control group was respectively 24.00%(12/50)and 28.00%(14/50),with no statistically significant difference(P>0.05).CONCLUSIONS:Yangzheng Touxie Qudu method combined with NAC regimen in the treatment of patients with triple negative breast cancer can significantly improve the efficacy and T cell subsets levels,reduce inflammatory reactions,and improve cancer-related fatigue with higher safety.