依达拉奉右莰醇辅助高频rTMS对轻度认知功能障碍患者神经元保护、氧化应激及认知功能的改善作用

Effects of High-Frequency Repetitive Transcranial Magnetic Stimulation Assisted by Edaravone and Camphor on Neuronal Protection,Oxidative Stress and Cognitive Function Improvement in Patients with Mild Cognitive Impairment

目的:探讨依达拉奉右莰醇辅助高频重复经颅磁刺激(rTMS)对轻度认知功能障碍(MCI)患者神经元保护、氧化应激及认知功能的改善作用。方法:选取2022年3月至2023年4月河北省沧州中西医结合医院收治的MCI患者100例,采取抽签法分为观察组和对照组,各50例。对照组患者接受高频rTMS治疗,观察组患者在对照组基础上加用依达拉奉右莰醇辅助治疗。观察两组患者的疗效、不良反应,比较治疗前后美国国立卫生院卒中神经功能缺损评分量表(NIHSS)、简易精神状态检查量表(MMSE)和蒙特利尔认知评测量表(MoCA)评分,血清丙二醛(MDA)、髓过氧化物酶(MPO)、超氧化物歧化酶(SOD)、神经元特异性烯醇化酶(NSE)、血浆脑钠肽(BNP)和C反应蛋白(CRP)水平。结果:观察组患者治疗总有效率为94.00%(47/50),显著高于对照组的78.00%(39/50),差异有统计学意义(P<0.05)。治疗后,两组患者的MMSE评分、MoCA评分均升高,且观察组患者高于对照组,差异均有统计学意义(P<0.05);两组患者的NIHSS评分均降低,且观察组患者低于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组患者的MDA、NSE、BNP、CRP和MPO水平低于对照组及治疗前,SOD水平高于对照组及治疗前,差异均有统计学意义(P<0.05)。观察组、对照组患者在治疗期间的不良反应发生率分别为10.00%(5/50)、4.00%(2/50),差异无统计学意义(P>0.05)。结论:依达拉奉右莰醇辅助rTMS治疗MCI患者,能明显改善其认知功能,促进神经元修复,减轻氧化应激反应,提高临床疗效。

OBJECTIVE:To probe into the effects of high-frequency repetitive transcranial magnetic stimulation(rTMS)assisted by edaravone and camphor on neuronal protection,oxidative stress and cognitive function Improvement in patients with mild cognitive impairment(MCI).METHODS:Totally 100 patients with MCI admitted into Hebei Cangzhou Hospital of Integrated Chinese and Western Medicine from Mar.2022 to Apr.2023 were extracted to be divided into the observation group and control group via the lottery method,with 50 cases in each group.The control group received high-frequency rTMS treatment,while the observation group was given adjuvant treatment with edaravone and camphor on the basis of the control group.The therapeutic efficacy and adverse drug reactions of two groups were observed,and the Neurological Function Scale(NIHSS),Simplified Mental State Evaluation Scale(MMSE),and Montreal Cognitive Assessment Scale(MoCA)scores and serum levels of malondialdehyde(MDA),myeloperoxidase(MPO),superoxide dismutase(SOD),neuron specific enolase(NSE),plasma brain natriuretic peptide(BNP),and C-reactive protein(CRP)of two groups were compared.RESULTS:The total effective rate of observation group was 94.00%(47/50),significantly higher than that 78.00%(39/50)of control group,the difference was statistically significant(P<0.05).After treatment,the MMSE and MoCA scores of both groups increased,and the observation group was higher than the control group,with statistically significant differences(P<0.05).After treatment,the NIHSS scores of both groups decreased,and the observation group was lower than the control group,with statistically significant differences(P<0.05).After treatment,MDA,NSE,BNP,CRP,MPO in the observation group were lower than those in the control group and before treatment,while SOD was higher than those in the control group and before treatment,with statistically significant differences(P<0.05).The incidence of adverse drug reactions in observation group and control group was respectively 10.00%(5/50)and 4.00%(2/50),with no statistically significant difference(P>0.05).CONCLUSIONS:rTMS assisted by edaravone and camphor in the treatment of patients with MCI can significantly improve cognitive function,promote neuronal repair,alleviate oxidative stress response,and improve clinical efficacy.