肠内免疫营养支持在更年期子宫内膜癌患者中的应用效果

Application effect of enteral immune nutrition support in endometrial cancer patients during climacteric period

目的探讨肠内免疫营养支持在更年期子宫内膜癌患者中的应用效果。方法根据干预方法的不同将78例更年期子宫内膜癌患者分为对照组(n=30)和观察组(n=48),对照组患者给予常规营养支持,观察组患者在对照组的基础上给予肠内免疫营养支持。比较两组患者的免疫功能指标、营养指标及肠内营养不耐受发生情况。结果干预后,两组患者CD3^(+)、CD4^(+)水平及CD4^(+)/CD8^(+)均高于本组干预前,CD8^(+)水平均低于本组干预前,观察组患者CD3^(+)、CD4^(+)水平及CD4^(+)/CD8^(+)均高于对照组,CD8^(+)水平低于对照组,差异均有统计学意义(P﹤0.05)。干预后,两组患者血红蛋白、免疫球蛋白G、血清总蛋白水平均高于本组干预前,观察组患者血红蛋白、免疫球蛋白G、血清总蛋白水平均高于对照组,差异均有统计学意义(P﹤0.05)。观察组患者肠内营养不耐受总发生率低于对照组(P﹤0.05)。结论肠内免疫营养支持能够改善更年期子宫内膜癌患者的免疫功能和营养状况,减少肠内营养不耐受的发生。

Objective To explore the application effect of enteral immune nutrition support in endometrial cancer pa-tients during climacteric period.Method According to different intervention methods,78 endometrial cancer patients during climacteric period were divided into control group(n=30)and observation group(n=48).The control group was given conventional nutritional support,and the observation group was given enteral immune nutritional support on the ba-sis of the control group.The immune function indexes,nutritional indexes and enteral nutritional intolerance were com-pared between the two groups.Result After intervention,the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in both groups were higher than those before intervention,and the levels of CD8^(+)were lower than those before intervention,the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in observation group were higher than those in control group,and the level of CD8^(+)was low-er than that in control group,and the differences were statistically significant(P<0.05).After intervention,the levels of hemoglobin,immunoglobulin G and serum total protein in both groups were higher than those before intervention,and the levels of hemoglobin,immunoglobulin G and serum total protein in observation group were higher than those in con-trol group,and the differences were statistically significant(P<0.05).The total incidence of enteral nutritional intolerance in observation group was lower than that in control group(P<0.05).Conclusion Enteral immune nutrition support can improve the immune function and nutritional status of endometrial cancer patients during climacteric period,and reduce the occurrence of enteral nutritional intolerance.