加速康复外科干预对宫颈癌根治术患者术后恢复、炎性反应的影响

Effect of enhanced recovery after surgery intervention on postoperative recovery and inflammatory response in patients undergoing radical hysterectomy for cervical cancer

目的探讨加速康复外科(ERAS)干预对宫颈癌根治术患者术后恢复、炎性反应的影响。方法选取60例宫颈癌患者,均接受宫颈癌根治术治疗,依据干预方式的不同分为观察组(n=33)和对照组(n=27),对照组患者给予常规干预,观察组患者在常规干预的基础上给予ERAS干预。比较两组患者的术后恢复指标、炎性因子指标[C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]、血压水平和并发症发生情况。结果观察组患者首次排气时间、首次下床活动时间、首次排便时间、住院时间均短于对照组,差异均有统计学意义(P﹤0.05)。术后第7天,两组患者CRP、IL-6、TNF-α水平均低于本组术后第1天,观察组患者CRP、IL-6、TNF-α水平均低于对照组,差异均有统计学意义(P﹤0.05)。术后15 min,两组患者舒张压、收缩压均高于本组术后5 min,观察组患者舒张压、收缩压均低于对照组,差异均有统计学意义(P﹤0.05)。观察组患者术后并发症总发生率低于对照组,差异有统计学意义(P﹤0.05)。结论ERAS干预能够促进宫颈癌根治术患者的术后恢复,减轻炎症反应、应激反应,降低并发症发生率。

Objective To explore the effect of enhanced recovery after surgery(ERAS)intervention on postoperative recovery and inflammatory response in patients undergoing radical hysterectomy for cervical cancer.Method Sixty pa-tients with cervical cancer were selected,and who of them were treated with cervical cancer radical surgery.They were di-vided into observation group(n=33)and control group(n=27)based on different intervention methods.Patients in control group received routine intervention,while patients in observation group received ERAS intervention on the basis of rou-tine intervention.The postoperative recovery indexes,inflammatory factors[C-reactive protein(CRP),interleukin-6(IL 6),tumor necrosis factorα(TNF-α)],blood pressure levels and complications were compared between the two groups.Result The first time of exhaust,first time of getting out of bed,the first time of defecation and hospital stay time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).On the 7th day after surgery,the levels of CRP,IL-6 and TNF-αin two groups were lower than those before surgery,and the levels of CRP,IL-6 and TNF-αin observation group were lower than those in control group,and the differences were statistically significant(P<0.05).At 15 min after surgery,the diastolic blood pressure and systolic blood pressure in two groups were higher than those at 5 min after surgery,and the diastolic blood pressure and systolic blood pressure in obser-vation group were lower than those in control group,and the differences were statistically significant(P<0.05).The total incidence of postoperative complications in observation group was lower than that in control group,and the difference was statistically significant(P<0.05).Conclusion ERAS intervention can promote postoperative recovery in patients un-dergoing radical hysterectomy for cervical cancer,reduce inflammatory,stress reactions and the incidence of complications.