显微镜下肿瘤切除术治疗脑胶质瘤患者的疗效及术后复发的影响因素分析

Analysis of the therapeutic effect of microscopic tumor resection in the treatment of brain glioma patients and the influencing factors of postoperative recurrence

目的探讨显微镜下肿瘤切除术治疗脑胶质瘤患者的疗效及术后复发的影响因素。方法收集82例显微镜下肿瘤切除术脑胶质瘤患者的病历资料,统计所有患者的手术切除范围、并发症发生情况以及随访1年的术后复发情况,并采用Logistic回归模型分析显微镜下肿瘤切除术脑胶质瘤患者术后复发的影响因素。结果82例显微镜下肿瘤切除术脑胶质瘤患者中,肿瘤全切59例(71.95%),肿瘤次全切23例(28.05%);术后发生语言不利1例,头晕头痛2例,并发症总发生率为3.66%(3/82)。Logistic回归分析结果显示,年龄、肿瘤直径、病理分级、手术切除范围及术后放化疗情况均是显微镜下肿瘤切除术脑胶质瘤患者术后复发的影响因素(P﹤0.05)。结论显微镜下肿瘤切除术脑胶质瘤患者的肿瘤全切除率高,并发症发生率低。年龄、肿瘤直径、病理分级、手术切除范围及术后放化疗情况均是显微镜下肿瘤切除术脑胶质瘤患者术后复发的影响因素。

Objective To investigate the therapeutic effect of microscopic tumor resection in the treatment of brain glioma patients and the influencing factors of postoperative recurrence.Method The medical records of 82 patients with brain glioma who underwent microscopic tumor resection were collected.The range of surgical resection,complications and postoperative recurrence after 1 year follow-up of all patients were counted.The influencing factors of postoperative recurrence of patients with brain glioma who underwent microscopic tumor resection were analyzed by Logistic regres-sion model.Result Among the 82 patients who underwent microscopic tumor resection,59 cases(71.95%)underwent total tumor resection,and 23 cases(28.05%)underwent subtotal tumor resection.There was 1 case of impaired speech and 2 cases of dizziness and headache in these patients,and the total incidence of complication was 3.66%(3/82).Logis-tic regression analysis showed that age,tumor diameter,pathological grade,range of surgical resection and postoperative chemoradiotherapy were influencing factors of postoperative recurrence in patients with brain glioma who underwent mi-croscopic tumor resection(P<0.05).Conclusion The total tumor resection rate of brain glioma patients undergoing mi-croscopic tumor resection is high and the incidence of complication is low.Age,tumor diameter,pathological grade,range of surgical resection and postoperative chemoradiotherapy are influencing factors of postoperative recurrence in pa-tients with brain glioma undergoing microscopic tumor resection.