STIL基因在恶性肿瘤发生发展中的作用研究进展

Research progress on the role of the STIL gene in the occurrence and development of malignant tumors

SCL/TAL1中断位点蛋白(STIL)是一种参与有丝分裂纺锤体检查点调节相关的胞质蛋白,通过调节中心体复制参与细胞的有丝分裂和恶性转变。其在肿瘤中表达上调,与胃癌、肝癌、胰腺癌、卵巢癌、乳腺癌、前列腺腺癌以及骨肉瘤等肿瘤的发生发展密切相关;并且可通过各种机制影响恶性肿瘤的发生发展。敲除STIL可抑制肿瘤细胞增殖、侵袭、迁移,这一发现表明STIL可视为肿瘤治疗的潜在治疗靶点。因此,深入研究STIL基因在恶性肿瘤中的表达、生物学功能和调控机制,可以为恶性肿瘤患者的早期诊断和靶向治疗提供新思路。

SCL/TAL1 interrupting locus(STIL)is a cytosolic protein involved in the regulation of mitotic spindle checkpoints,mitosis and malignant transformation of cells by mediating centrosome replication.It is overexpressed in tumors,and closely related to the occurrence and development of gastric cancer,liver cancer,pancreatic cancer,ovarian cancer,breast cancer,prostate adenocarcinoma and osteosarcoma.STIL influences the occurrence and development of malignant tumors via various mechanisms.Knockout of STIL can inhibit tumor cell proliferation,invasion and migration,indicating that STIL can be regarded as a potential therapeutic target for tumor therapy.Therefore,in-depth study of the expression,biological function and regulatory mechanism of the STIL gene in malignant tumors can provide new ideas for early diagnosis and targeted therapy of patients with malignant tumors.