骨伤复原汤联合髋关节置换术对股骨颈骨折患者血液流变学及骨代谢指标的影响

The Effects of Bone Injury Recovery Decoction Combined withHip Replacement Surgery on Hemorheology and Bone MetabolismIndicators in Patients with Femoral Neck Fractures

目的:观察骨伤复原汤联合髋关节置换术对股骨颈骨折患者血液流变学及骨代谢指标的影响。方法:将75例股骨颈骨折患者随机分为对照组37例和观察组38例。对照组给予髋关节置换术及术后常规治疗,观察组在对照组治疗的基础上给予骨伤复原汤治疗。比较两组患者治疗前后炎性因子[白细胞介素(interleukin,IL)-6、TL-1β、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)]、血液流变学指标、骨代谢指标及髋关节功能评分变化情况。结果:两组患者治疗后IL-6、IL-1β、TNF-α、血浆黏度、全血高切黏度、全血低切黏度均低于本组治疗前,且观察组治疗后低于对照组(P<0.05)。两组患者治疗后血清骨钙素、骨特异性碱性磷酸酶均高于本组治疗前,抗酒石酸酸性磷酸酶-5b低于本组治疗前,且治疗后组间比较,差异具有统计学意义(P<0.05)。两组患者治疗后Harris评分高于本组治疗前,且观察组治疗后高于对照组,差异具有统计学意义(P<0.05)。结论:骨伤复原汤联合髋关节置换术能够降低股骨颈骨折患者术后炎性因子水平,改善血液流变学及骨代谢指标,促进关节功能恢复。

Objective:To observe the effects of Bone Injury Recovery Decoction combined with hip replacement surgery on hemorheology and bone metabolism indicators in patients with femoral neck fractures.Methods:A total of 75 patients with femoral neck fractures were divided into the control group(37 cases)and the observation group(38 cases)using an odd-even method.The control group received hip replacement surgery and routine postoperative treatment,while the observation group was treated with Bone Injury Recovery Decoction in addition to the treatment received by the control group.The Changes in inflammatory factors[including interleukin(IL)-6,IL-1β,tumor necrosis factor-α(TNF-α)],hemorheology indicators,bone metabolism indicators,and hip joint function scores were compared between the two groups before and after treatment.Results:After treatment,the levels of IL-6,IL-1β,TNF-α,plasma viscosity,whole blood high shear viscosity,and whole blood low shear viscosity were significantly lower in both groups compared to their respective pretreatment levels,with the observation group showing lower levels than the control group(P<0.05).Serum osteocalcin and bone-specific alkaline phosphatase levels increased,while tartrate-resistant acid phosphatase-5b levels decreased in both groups after treatment.Statistically significant differences were observed between the two groups after treatment(P<0.05).Harris scores for hip function were higher in both groups after treatment,with the observation group showing significantly higher scores than the control group,and the difference was statistically significant(P<0.05).Conclusion:Bone Injury Recovery Decoction combined with hip replacement surgery can reduce postoperative inflammatory status,improve hemorheology and bone metabolism,and promote functional recovery in patients with femoral neck fractures.