益气养阴补肾活血方治疗早期糖尿病肾病临床研究

Clinical Study on the Treatment of Early Diabetic Nephropathy with Qi-Boosting and Yin-Nourishment and Kidney-Tonifying and Blood-Activating Decoction

目的:观察益气养阴补肾活血方治疗早期糖尿病肾病的临床疗效。方法:将成都市双流区中医医院治疗的60例早期糖尿病肾病患者作为研究对象,按照随机数字表法分为常规组和观察组,每组30例。常规组给予西药常规疗法治疗,观察组在常规组治疗的基础上加用益气养阴补肾活血方治疗。观察两组治疗前后血糖[空腹血糖(Fasting blood glucose,FBG)、餐后2 h血糖(2 hours postprandial blood glucose,2 hPG)、糖化血红蛋白(glycosylated hemoglobin,HbA1c)]、血脂[三酰甘油(three acyl glycerin,TG)、总胆固醇(total cholesterol,TC)]、肾功能指标[24 h尿蛋白、β2-微球蛋白(β2-Microglobulin,β2-MG)、血肌酐(serum creatinine,Scr)、尿白蛋白排泄率(urinary albumin excretion rates,UAER)]和不良反应的变化情况。结果:常规组有效率为86.67%,观察组有效率为93.33%,观察组有效率高于常规组,差异有统计学意义(P<0.05)。两组治疗后FBG、2 hPG、HbA1c均低于治疗前,且观察组低于常规组,但组间比较,差异无统计学意义(P<0.05)。观察组治疗后TC、TG低于常规组,差异有统计学意义(P<0.05)。观察组治疗后24 h尿蛋白定量、β2-MG、UAER水平低于常规组,差异有统计学意义(P<0.05),观察组治疗后Scr也低于常规组,但差异无统计学意义(P>0.05)。观察组不良反应发生率为13.33%,常规组不良反应发生率为23.33%,观察组不良反应发生率低于常规组,差异有统计学意义(P<0.05)。结论:益气养阴补肾活血方治疗早期糖尿病肾病,能降低患者血糖、血脂水平,改善患者肾功能,且不良反应少。

Objective:To observe the clinical efficacy of Qi-Boosting and Yin-Nourishment and Kidney-Tonifying and Blood-Activating Decoction on early diabetic nephropathy.Methods:A total of 60 patients with early diabetic nephropathy treated in Chengdu Shuangliu District Hospital of Traditional Chinese Medicine were selected as the research subjects,and were divided into the routine group and the observation group according to the clinical manifestations of the patients,with 30 cases in each group.The routine group was given conventional western medicine therapy,while the observation group was treated with Qi-Boosting and Yin-Nourishment and Kidney-Tonifying and Blood-Activating Decoction on the basis of the routine group.The changes in blood glucose[including fasting blood glucose(FBG),2 hours postprandial blood glucose(2 hPG),glycosylated hemoglobin(HbA1c)],blood lipids[including three acyl glycerin(TG),total cholesterol(TC)],renal function indexes[including 24-hour urinary protein,β2-microglobulin(β2-MG),serum creatinine(Scr),urinary albumin excretion rates(UAER)]and adverse reactions of the two groups before and after treatment were observed.Results:The effective rate of the routine group was 86.67%,while that of the observation group was 93.33%,with a statistically significant difference(P<0.05).After treatment,the FBG,2 hPG and HbA1c of the two groups were lower than those before treatment,and the observation group′s above indexes were lower than those of the conventional group,but there were no statistically significant differences(P<0.05);TC and TG in the observation group were lower than those in the routine group,with statistically significant differences(P<0.05);the levels of 24 h urinary protein,β2-MG and UAER in the observation group were lower than those in the routine group,with statistically significant differences(P<0.05);Scr in the observation group was also lower than that in the routine group,but the difference was not statistically significant(P>0.05).The incidence of adverse reactions in the observation group was 13.33%,while that in the routine group was 23.33%.The incidence of adverse reactions in the observation group was lower than that in the routine group,with a statistically significant difference(P<0.05).Conclusion:Qi-Boosting and Yin-Nourishment and Kidney-Tonifying and Blood-Activating Decoction in the treatment of early diabetic nephropathy can reduce blood glucose and blood lipids,improve renal function,and has fewer adverse reactions.