抑郁倾向Wilson病患者的注意偏向特征及与反刍思维的关系研究

A study on the characteristics of attention bias in Wilson′s disease patients with depressive tendencies and its relationship with rumination

目的 探究抑郁倾向Wilson病(WD)患者的注意偏向特征及与反刍思维的关系。方法 招募2022年1月至2023年1月安徽中医药大学神经病学研究所附属医院收治的WD患者51例,根据贝克抑郁量表(BDI)评分将其分为抑郁组(≥5分,30例)和非抑郁组(≤4分,21例)。比较两组反刍思维量表(RRS)评分及情绪Stroop范式试验结果,并分析观察指标间的关联性。结果 抑郁组在RRS的症状反刍、反省深思、强迫思考维度得分及总分均高于非抑郁组,差异有统计学意义(P<0.05)。抑郁组对负性词的反应时间显著慢于非抑郁组(P<0.05);两组对中性词及正性词的反应时间比较差异无统计学意义(P>0.05)。WD患者对负性词反应时间与BDI评分、RRS总分、RRS的症状反刍维度得分呈正相关(P<0.05),对正性词和中性词反应时间与BDI评分、RRS总分及RRS各维度得分的相关性不显著(P>0.05)。多因素线性回归分析结果显示,BDI评分、RRS总分、RRS的症状反刍维度得分是WD患者对负性词反应时间的影响因素(P<0.05)。结论 抑郁倾向WD患者会过多关注负性情绪信息,反刍思维可能是导致抑郁倾向WD患者负性情绪注意偏向的原因之一。

Objective To explore the characteristics of attention bias in Wilson′s disease(WD)patients with depressive tendencies and its relationship with rumination.Methods A total of 51 WD patients admitted to Affiliated Hospital of Institute of Neurology,Anhui University of Chinese Medicine from January 2022 to January 2023 were recruited.According to Beck Depression Inventory(BDI)scores,the patients were divided into depression group(≥5 points,30 cases)and non-depression group(≤4 points,21 cases).The results of Ruminative Responses Scale(RRS)scores and emotional Stroop paradigm were compared between the two groups,and the correlation between the observation indicators was analyzed.Results The dimension scores of rumination symptoms,introspection and forced thinking in RRS and the total scores of RRS in the depression group were higher than those in the non-depression group,and the differences were statistically significant(P<0.05).The response time to negative words in the depression group was significantly longer than that in the non-depression group(P<0.05).There was no significant difference in the response time to neutral words and positive words between the two groups(P>0.05).In the WD patients,the response time to negative words was positively correlated with BDI scores,total RRS scores and the dimension scores of rumination symptoms in RRS(P<0.05),and there was no significant correlation of the response time to positive words and the response time to neutral words with BDI scores,total RRS scores and each dimension scores of RRS(P>0.05).The results of multi-factor linear regression analysis showed that BDI scores,total RRS scores and the dimension scores of rumination symptoms in RRS were the influencing factors of the response time of the WD patients to negative words(P<0.05).Conclusion The WD patients with depressive tendencies tend to pay too much attention to negative emotional information.Rumination may be one of the causes of negative emotional attention bias in the WD patients with depressive tendencies.