中药有效成分和复方调控干燥综合征相关信号通路研究进展

Research Progress on the Regulation of Sjogren's Syndrome-Related Signaling Pathways by Effective Components and Formulas of Traditional Chinese Medicine

干燥综合征(SS)是一种以侵犯外分泌腺,尤其是唾液腺及泪腺为主的慢性自身免疫性疾病。中医药对于SS的研究多从调节免疫、降低炎症反应、上调水通道蛋白等角度出发,体现出多靶点、多层次、多途径的作用优势。近年来众多学者基于SS发病的相关信号通路开展了大量研究,发现中药通过调控SS相关的Toll样受体信号通路、干扰素信号通路、JAK/STAT信号通路、NF-κB信号通路、PD-1/PD-L1信号通路、PI3K/Akt信号通路等,起到抑制炎症反应及调节免疫的作用,进而防治SS。本文旨在探讨相关信号通路在SS发病机制中的具体作用以及中药在调控这些信号通路方面的研究成果,以期为中药治疗SS的深入研究提供参考和思路。

Sjogren's Syndrome(SS)is a chronic autoimmune disease primarily affecting the exocrine glands,especially the salivary and lacrimal glands.Research on Traditional Chinese Medicine(TCM)for Sjogren's Syndrome often focuses on regulating the immune system,reducing inflammatory responses,and upregulating water channel proteins,reflecting its multi-target,multi-level,and multi-pathway advantages.In recent years,numerous scholars have conducted extensive studies on the relevant signaling pathways involved in the pathogenesis of SS.It has been found that TCM can modulate SS-related signaling pathways such as Toll-like receptor signaling,interferon signaling,JAK/STAT signaling,NF-κB signaling,PD-1/PD-L1 signaling,and PI3K/Akt signaling pathways,thereby inhibiting inflammation and regulating immunity to prevent and treat SS.This paper aims to explore the specific roles of these signaling pathways in the pathogenesis of SS and the research achievements of TCM in regulating these pathways,providing references and ideas for further in-depth research on TCM treatment for Sjogren's Syndrome.