开展1-3-β-D-葡聚糖试验和半乳甘露聚糖抗原试验全国室间质评的重要性

The importance of launching the national external quality assessment of 1-3-β-D-glucan test and galactomannan antigen test

侵袭性真菌病发病率逐年升高,已成为困扰临床科室的严重感染性疾病之一。目前侵袭性真菌病早期诊断的重要检测指标是1-3-β-D-葡聚糖试验和半乳甘露聚糖抗原试验,即G试验和GM试验。国家卫生健康委员会在《国家医疗质量安全改进目标》之目标四中提出“提高住院患者抗菌药物治疗前病原学送检率”,同时强调G试验等项目作为临床常见真菌学检测项目的重要性。而如何保证临床实验室真菌检测项目质量就显得非常重要。该文就影响G试验和GM试验检测的关键因素及开展全国室间质评的重要性进行了详细阐述。

The incidence of invasive fungal diseases has been increasing annually,becoming one of the most serious infectious diseases affecting clinical departments.Currently,the primary indicators for early diagnosis of invasive fungal disease are the 1-3-β-D-glucan test and the galactomannan antigen test,known as the G test and GM test,respectively.The National Health Commission of the People′s Republic of China,in Goal Four of the'National Medical Quality and Safety Improvement Goals′,proposed to'increase the submission rate of pathogen examination before antibiotic treatment in hospitalized patients′,and emphasized the importance of tests such as G test as common clinical mycological diagnostic tools.Moreover,it is of paramount significance for clinical laboratories to ensure the quality of fungal detection.This paper provides a detailed discussion of the key factors affecting the G test and GM test,and the importance of launching the national external quality assessments.