外泌体在情志病发生、发展及治疗中的作用

Role of exosomes in the occurrence,development and treatment of emotional diseases

中医情志病以郁证、癫狂、脏躁为主,与现代的抑郁症、焦虑症等中枢神经系统疾病相对应,治疗药物因血脑屏障无法直接作用靶点,亟需开发更加有效的治疗方法。外泌体在细胞间通讯中有十分重要的作用,并作用于中枢神经系统疾病发生发展过程,其作为疾病诊断及治疗靶点的潜力也逐渐凸显。文章阐述了外泌体的生物特性,并从其对情志病的发生发展、诊断治疗两个方面探讨外泌体早期诊断及靶向治疗的潜力,最后联系中医证候与外泌体的关系,对外泌体作为中医病证结合生物学基础的前景进行了展望。

The emotional diseases of traditional Chinese medicine(TCM)are mainly depression,madness,and visceral mania,which are corresponding to modern central nervous system diseases such as depression and anxiety.Therapeutic drugs cannot directly act on the target because of the blood-brain barrier,so there is an urgent need to develop more effective treatment methods.Exosomes play a very important role in intercellular communication and are used in the occurrence and development of central nervous system diseases,and their potential as disease diagnosis and treatment targets has gradually become prominent.This paper expounds the biological characteristics of exosomes,and discusses the potential of early diagnosis and targeted treatment of exosomes from two aspects of occurrence and development,diagnosis and treatment of emotional diseases.Finally,in connection with the relationship between TCM syndrome and exosomes,the prospect of exosomes as the biological basis of TCM diseaseand syndromeis prospected.