抗Ro52抗体在结缔组织病中的研究进展

Advances in the study of anti-Ro52 antibodies in connective tissue disease

Ro52蛋白是三基序蛋白家族成员之一, 通过参与细胞分化, 凋亡, 转录调控和信号通路等生物过程, 与结缔组织病的发生发展密切相关。抗Ro52抗体是结缔组织病中最为常见的自身抗体之一, 在不同结缔组织病中与临床症状以及疾病预后相关。抗Ro52抗体与间质性肺疾病密切相关, 尤其是在干燥综合征和特发性炎症性肌病中。然而, 抗Ro52抗体的具体致病机制尚未完全清楚。抗Ro52抗体经常与其他自身抗体共同出现, 而抗Ro52抗体单独阳性在结缔组织病中所占比例较低, 临床意义尚未明确, 部分研究似乎表明单独的抗Ro52抗体对疾病进展起保护作用, 但还需要进一步的研究。

Ro52 protein is a member of the triple motif protein family and is closely associated with the development of connective tissue diseases through its involvement in biological processes such as cell differentiation,apoptosis,transcriptional regulation and signaling pathways.Anti-Ro52 antibodies are among the most common autoantibodies in connective tissue diseases and are associated with clinical symptoms and disease prognosis in different connective tissue diseases.Anti-Ro52 antibodies are closely associated with interstitial lung disease,particularly in primary Sjogren syndrome and idiopathic inflammatory myopathies.However,the specific pathogenic mechanism of anti-Ro52 antibodies is not fully understood.Anti-Ro52 antibodies are often found in combination with other autoantibodies,while isolated anti-Ro52 antibodies are less prevalent in connective tissue disease and their clinical significance is not yet clear.Some studies seem to indicate that isolated anti-Ro52 antibodies play a protective role against disease progression,but further studies are needed.