T/B淋巴细胞参与多发性硬化发病机制的研究进展

The interaction of T and B cells in the pathogenesis of multiple sclerosis

多发性硬化(multiple sclerosis, MS)长期以来被认为是一种主要由T细胞介导的器官特异性自身免疫疾病, 并涉及多种其他类型的淋巴细胞。然而, 临床上使用抗CD20 B细胞耗竭疗法(B cell depletion therapy, BCDT)治疗MS取得了出人意料的效果, 说明B细胞在MS中扮演了重要角色。该疗法对MS中B细胞的抗原递呈功能产生影响, 而对产生抗体的功能无影响, 表明B细胞与T细胞的相互作用是MS发病的重要驱动因素, 文章旨在通过对MS中B细胞和T细胞的相互作用进行分析, 以深化对MS免疫学机制的理解。

Multiple sclerosis(MS)is an autoimmune disease involving multiple lymphocytes and has long been recognized as a T cell-mediated organ-specific disease.However,the clinical efficacy of anti-CD20 B-cell depletion therapy(BCDT)was unexpected,highlighting the important role of B cells in MS.This therapy has an effect on the antigen presenting function of B cells in MS,but has no effect on the function of producing antibodies,indicating that the interaction between B cells and T cells is an important driving factor in the pathogenesis of MS.In this paper,the interaction of T and B cells in MS is reviewed in order to further understand the immunological pathogenesis of MS.