肠屏障与中枢神经系统疾病关系的研究进展

Research progress in the relationship between intestinal barrier and central nervous system diseases

肠屏障是肠道能够防止肠内的微生物及其相关产物穿过肠黏膜进入人体内的结构和功能的总和,在人体健康和疾病中发挥关键作用。肠屏障在其管腔侧与肠道微生物群紧密接触,在其组织侧与肠神经元和神经胶质细胞紧密接触。越来越多的证据表明,肠道屏障不仅在维护肠功能中起重要作用,而且也与中枢神经系统(central nervous system,CNS)的发病有关,如帕金森病、孤独症谱系障碍、抑郁症、多发性硬化症和阿尔茨海默病等。了解CNS疾病患者肠屏障功能的改变对于研究CNS疾病的病因、寻求新的治疗方法具有重要意义,文章就肠屏障及其在CNS疾病中的潜在作用作一综述。

Intestinal barrier is the sum of structures and functions that can prevent intestinal microorganisms and their related products from passing through the intestinal mucosa into the human body,and plays a key role in human health and disease.The intestinal barrier is in close contact with intestinal microflora at the lumen side,and with intestinal neurons and glial cells at the tissue side.More and more evidence shows that intestinal barrier not only plays an important role in maintaining intestinal function,but also is related to the pathogenesis of central nervous system(CNS),such as Parkinson's disease,autism spectrum disorder,depression,multiple sclerosis and Alzheimer's disease.Understanding the changes of intestinal barrier function in patients with CNS diseases is of great significance for studying the etiology of CNS diseases and seeking new treatment methods.The review summarizes the intestinal barrier and its potential role in CNS diseases.