逆境条件下药用植物酚酸类物质“内外大循环”代谢及作用机制探讨

Study on Metabolism in‘Internal and External Circulation’and Action Mechanism of Phenolic Acids in Medicinal Plants under Adverse Stress

逆境胁迫是植物进化过程中必不可少的驱动因子,关于植物应对逆境胁迫的适应机制研究日趋深入。植物体内的次生代谢物含量中酚酸类大约占到30%,它具有抗微生物、抗氧化、抗细胞毒性和抗炎的作用,是植物抗逆胁迫过程中的主要“功臣”,也是药用植物发挥临床药效的重要物质基础。前期研究发现,连作条件下丹参植株体内的酚酸类成分含量增加,根际的邻苯二甲酸、苯甲酸等物质能够促进立枯丝核菌增殖,致使连作丹参木质素合成增加,提升植物对病原菌侵染的防御能力。故而本研究对酚酸类次生代谢物在药用植物体内合成以及体外代谢的“全链条”代谢途径进行综合探讨,总结酚酸类次生代谢物合成及分泌的全过程,以期为药用植物抗逆、抗病应答研究提供理论支撑。

Adverse stresses are indispensable driving factors in plant evolution,and researches on the a-daptive mechanisms of plants to adverse stresses are gradually deepened.Phenolic acids account for about 30%of plant secondary metabolites,and have anti-microbial,anti-oxidant,anti-cytotoxic and anti-inflammatory effects,so they are the main contributors to the process of plant adversity stress resistance and the important material basis for the clinical efficacy of medicinal plants.Previous studies indicated that the content of phenol-ic acids in Salvia divinorum plants increased under continuous cropping conditions,and rhizosphere phthalic acid and benzoic acid could promote the proliferation of Rickettsia sp.,resulting in the increase of lignin syn-thesis in continuous cropping S.divinorum,and enhancing plant defense against phytopathogens.This study discussed the whole chain of metabolic pathways of phenolic acids synthesized in vivo and metabolized in vitro,and summarized the whole process of phenolic acids synthesis and secretion,hoping to provide theoretical sup-ports for medicinal plants response to adversity and disease resistance.