白头翁汤及其加减方治疗溃疡性结肠炎研究进展

Research Progress of Baitouweng Decoction and Its Modified Prescription in the Treatment of Ulcerative Colitis

白头翁汤为热毒痢疾常用经典方剂,治疗溃疡性结肠炎疗效显著。临床研究发现,白头翁汤原方或加味、联合其他中药或其他疗法治疗溃疡性结肠炎,可改善患者临床症状,降低肠镜下病变活动评分,促进肠黏膜组织愈合,同时还可提高治疗的总有效率,减少不良反应,降低复发率。药理研究表明,白头翁汤可能通过调控相关炎症因子及信号通路表达、调节免疫功能、修复肠黏膜屏障、改善肠道菌群失调等方面治疗溃疡性结肠炎。本文梳理白头翁汤治疗溃疡性结肠炎临床和基础研究进展,为相关研究提供参考。

Baitouweng Decoction is a classic prescription commonly used in the treatment of heat-toxin dysentery,with confirmed efficacy in the treatment of ulcerative colitis(UC).Clinical studies have found that Baitouweng Decoction,modified Baitouweng Decoction,combined with other Chinese materia medica or other therapies for UC can improve the clinical symptoms of patients,reduce the lesion activity score under colonoscopy,promote the healing of intestinal mucosal tissue,and also improve the overall efficiency of treatment,and reduce adverse reactions and recurrence rate.Pharmacological studies showed that Baitouweng Decoction may treat UC by regulating the expressions of related inflammatory factors and signaling pathways,regulating immune function,repairing intestinal mucosal barrier,and improving intestinal flora imbalance.This article systematically reviewed the clinical and basic research progress of Baitouweng Decoction in the treatment of UC,in order to provide a basis for relevant research.