摘要
童年期创伤与抑郁症的康复和预后有关,目前认为伴童年期创伤抑郁症的发生是基因和环境相互作用的结果,同时非同质的神经生物学机制也参与其中。基因多态性又称为遗传多态性,是指在某一个生物群体中,同时或经常存在两种或者多种不连续变异的基因。研究发现伴童年期创伤抑郁症可能与神经递质系统、下丘脑-垂体-肾上腺轴、脑源性神经营养因子、炎症等基因多态性相关。本文通过对抑郁症相关候选基因多态性进行综述,以期揭示伴童年期创伤抑郁症患者潜在的发病机制,为抑郁症早期诊断、治疗提供理论依据。
Childhood trauma is associated with the recovery and prognosis of depressive disorder.It is believed that the occurrence of depressive disorder accompanied by childhood trauma is the result of the interaction between genes and environment,and non-homogeneous neurobiological mechanisms are also involved.Gene polymorphism,also known as genetic polymorphism,refers to the simultaneous or frequent presence of two or more discontinuous variations in a population of organisms.Research has found that childhood trauma and depressive disorder may be associated with gene polymorphisms in the neurotransmitter system,hypothalamic-pituitary-adrenal axis,brain-derived neurotrophic factor,and inflammation.This article reviews candidate gene polymorphisms related to depressive disorder,aiming to reveal the potential pathogenesis of depressive disorder patients with childhood trauma and provide theoretical basis for early diagnosis and treatment of depressive disorder.
作者
王霜
王学义
Wang Shuang;Wang Xueyi(Mental Health Center,the First Hospital of Hebei Medical University&Hebei Institute of Mental Health&Hebei Clinical Research Center for Mental Disorders&Hebei Technology Innovation Center for Mental and Psychological Health Assessment and Intervention,Shijiazhuang 050031,China)
出处
《神经疾病与精神卫生》
2024年第9期654-659,共6页
Journal of Neuroscience and Mental Health
基金
河北省省级科技计划资助项目(21377711D)
河北省引进国外智力项目(YZ202306)。
关键词
抑郁症
童年创伤
神经递质
候选基因多态性
综述
Depressive disorder
Childhood trauma
Neurotransmitters
Candidate gene polymorphism
Review