摘要
A good Ti-based joint implant should prevent stress shielding and achieve good bioactivity and anti-infection performance.To meet these requirements,the low-elastic-modulus alloy—Ti–35Nb–2Ta–3Zr—was used as the substrate,and functional coatings that contained bioceramics and Ag ions were prepared for coating on TiO_(2)nanotubes(diameter:(80±20)nm and(150±40)nm)using anodization,deposition,and spin-coating methods.The effects of the bioceramics(nano-β-tricalcium phosphate,microhydroxyapatite(micro-HA),and meso-CaSiO_(3))and Ag nanoparticles(size:(50±20)nm)on the antibacterial activity and the tribocorrosion,corrosion,and early in vitro osteogenic behaviors of the nanotubes were investigated.The tribocorrosion and corrosion results showed that the wear rate and corrosive rate were highly dependent on the features of the nanotube surface.Micro-HA showed great wear resistance with a wear rate of(1.26±0.06)×10^(−3)mm^(3)/(N·m)due to adhesive and abrasivewear.Meso-CaSiO_(3)showed enhanced cell adhesion,proliferation,and alkaline phosphatase activity.The coatings that contained nano-Ag exhibited good antibacterial activity with an antibacterial rate of≥89.5%against Escherichia coli.These findings indicate that hybrid coatings may have the potential to accelerate osteogenesis.
基金
supported by the National Natural Science Foundation of China(Nos.52071346,52111530193,and 52274387)
the Natural Science Foundation of Hunan Province for Distinguished Young Scholars(No.2023JJ10075)
the Hunan Provincial Natural Science Foundation of China(No.2021JJ30846)
the Central South University Research Program of Advanced Interdisciplinary Studies(No.2023QYJC038)
the Funding for the Medical Engineering Cross Disciplinary Project at Shanghai Jiao Tong University,and the Fundamental Research Funds for the Central Universities of Central South University(No.2022ZZTS0402)
The authors would also thank Sinoma Institute of Materials Research(Guangzhou)Co.,Ltd.for the assistance with the TEM characterization.
