基于数据挖掘探讨陈晓刚治疗儿童抽动障碍用药规律

Medication Law of Chen Xiaogang in the Treatment of Children with Tic Disorder Based on Data Mining

目的应用数据挖掘技术探讨陈晓刚主任中医师治疗儿童抽动障碍(TD)核心方药规律。方法收集2020年1月1日-2022年12月31日就诊于陈晓刚主任中医师门诊的TD患儿病例资料,采用Excel2021建立数据库,中医传承辅助平台V3.5进行数据挖掘,SPSS Modeler 18.0及SPSS27.0软件进行关联规则及聚类分析。结果共纳入处方532首,涉及患儿252例,常见症状及体征包括眨眼、睡眠欠佳、易发脾气、喉间发声、食欲不振等;涉及中药71味,高频药物有白芍、钩藤、蒺藜、僵蚕、合欢皮、天麻、龙骨、蝉蜕、防风、茯苓等;药性以平性为主,药味以甘、辛、苦味为主,归经以肝经、肺经、脾经为主。关联分析得到药对15个,聚类分析共得到药物组合4类。结论陈晓刚主任中医师辨治儿童TD提倡肝脾同调、肝肺同治,注重“治心调神”,身心共治,善用白芍,顺应小儿“脏腑娇嫩”生理特性。

Objective To explore the Chief TCM doctor Chen Xiaogang’s core prescriptions for the treatment of children’s tic disorder using data mining technology.Methods The case data of children with tic disorder who were treated in the outpatient department of Chief TCM doctor Chen Xiaogang from January 1,2020 to December 31,2022 were collected.Excel 2021 was used to establish a database,and TCM apprenticeship assistance platform V3.5 was used for data mining.SPSS Modeler 18.0 and SPSS 27.0 were used for association rules and clustering analysis.Results A total of 532 prescriptions were included in this study,involving 252 children.The common symptoms and signs included blinking,poor sleep,prone to tantrum,throat vocalization,loss of appetite and so on;involving 71 kinds of Chinese materia medica.The high frequency drugs were Paeoniae Radix Alba,Uncariae Ramulus cum Uncis,Tribuli Fructus,Bombyx Batryticatus,Albiziae Cortex,Gastrodiae Rhizoma,Os Draconis,Cicadae Periostracum,Saposhnikoviae Radix and Poria,etc.The drug property was mainly neutral,the tastes were mainly sweet,pungent and bitter,and the meridian tropism was mainly liver,lung and spleen meridians.15 drug pairs were obtained by association analysis and 4 drug combinations were obtained by clustering analysis.Conclusion Chief TCM doctor Chen Xiaogang advocates the harmonization of liver and spleen,simultaneous treatment for liver and lung for children with tic disorder,pays attention to“treating the heart and regulating the spirit”,with co-treatment of body and mind,and makes good use of Paeoniae Radix Alba to treat tic disorder,and adapts to the physiology of children with“delicate zang-fu organs”.