中医药治疗肺癌表皮生长因子受体酪氨酸激酶抑制剂相关性皮疹研究进展

Research Progress in TCM Diagnosis and Treatment of EGFR-TKI Related Rash in Lung Cancer

表皮生长因子受体酪氨酸激酶抑制剂(EGFR-TKI)相关性皮疹属中医学“药疹”“药毒”范畴,多从本虚标实、郁火、中阳虚损等角度进行辨证,治疗上强调祛风清热、宣散透解、祛湿解毒,同时滋阴养血、顾护肺脾。中医药治疗本病疗效显著,能改善患者生活质量,延长生存期。笔者检索近5年相关文献,对肺癌EGFR-TKI相关性皮疹的病因病机、辨证分型与治则、治疗等方面研究进行分析总结,为EGFR-TKI相关性皮疹的诊治提供新思路。

EGFR-TKI-related rash belongs to the category of“drug rash”or“drug toxicity”in TCM.Syndrome differentiation is mostly carried out from the perspectives of deficiency in origin and excess in superficiality,stagnation of fire,and deficiency of central yang.The treatment emphasizes the elimination of wind and heat,the promotion of dispersion and penetration,the elimination of dampness and detoxification,as well as the nourishing of yin and blood,and the care of lung and spleen.TCM has a good curative effect on treating this disease,which can improve the quality of life of patients and prolong the survival period.Therefore,the authors searched the relevant literature in the past five years,analyzed and summarized the etiology and pathogenesis,syndrome differentiation and treatment principles,and treatment of EGFR-TKI-related rash in lung cancer,in order to provide new ideas for the diagnosis and treatment of EGFR-TKI-related rash.