广西地区幽门螺杆菌感染与帕金森

Analysis of the Correlation between Helicobacter Pylori Infection and the Severity of Motor Symptoms in Parkinson’s Disease Patients in Guangxi Region

分析广西地区幽门螺杆菌感染与帕金森病患者运动症状严重程度的相关性。将广西科技大学第一附属医院2022年1月—2023年12月收治的70例帕金森病患者纳入试验组,将广西科技大学第一附属医院同期的70例健康人员纳入参照组。对组间人员基本资料进行收集,实施碳-14尿素呼气试验,进行UPDRS PartⅢ评分,研究幽门螺杆菌感染与帕金森病患者血清维生素B12、帕金森病评定量表评分之间的相关性。结果显示,试验组的碳-14尿素呼气试验中幽门螺杆菌阳性率高于参照组(P<0.05);试验组和参照组的血清维生素B12水平比较,无统计学差异(P>0.05);试验组中幽门螺杆菌阳性组和阴性组的血清维生素B12水平比较,无统计学差异(P>0.05);幽门螺杆菌阳性组的UPDRS PartⅢ评分高于阴性组,组间数据差异具有统计学意义(P<0.05)。研究发现,感染幽门螺杆菌易加重帕金森病患者的运动症状,两者之间关系密切,值得探讨。

Analyze the correlation between Helicobacter pylori infection and the severity of motor symptoms in Parkinson’s disease patients in Guangxi region.Seventy Parkinson’s disease patients admitted to the First Affiliated Hospital of Guangxi University of Science and Technology from January 2022 to December 2023 were included in the experimental group,and 70 healthy individuals from the same period were included in the reference group.Collect basic information of intergroup personnel,conduct carbon-14 urea breath test,conduct UPDRS PartⅢscoring,and study the correlation between Helicobacter pylori infection and serum vitamin B12 and Parkinson’s disease assessment scale scores in Parkinson’s disease patients.The results showed that the positive rate of Helicobacter pylori in the carbon-14 urea breath test of the experimental group was higher than that of the reference group(P<0.05);There was no statistically significant difference(P>0.05)in the serum vitamin B12 levels between the experimental group and the reference group;There was no statistically significant difference(P>0.05)in the serum vitamin B12 levels between the Helicobacter pylori positive and negative groups in the experimental group;The UPDRS PartⅢscore of the Helicobacter pylori positive group was higher than that of the negative group,and the difference in data between the groups was statistically significant(P<0.05).Research has found that infection with Helicobacter pylori can exacerbate motor symptoms in Parkinson’s disease patients,and the close relationship between the two is worth exploring.