沙库巴曲缬沙坦治疗维持性血液透析合并心力衰竭的效果评价

Evaluation of the Efficacy of Sacubitril Valsartan in the Treatment of Maintenance Hemodialysis Complicated with Heart Failure

分析沙库巴曲缬沙坦治疗维持性血液透析合并心力衰竭的效果。选取2022年1月—2022年12月医院收治的58例维持性血液透析合并心力衰竭患者为研究对象。采用随机数字表法将患者分为对照组和观察组,每组各29例。对照组实施常规对症治疗,观察组在对照组基础上实施沙库巴曲缬沙坦治疗,比较两组患者的治疗效果。结果显示,治疗后,观察组患者的心电图结果优于对照组(P<0.05);治疗后,观察组肾小球滤过率较高,血肌酐、尿素氮水平较低(P<0.05);治疗后,观察组患者的各项血生化指标均优于对照组(P<0.05);治疗后2周与1个月,观察组患者的运动耐力均优于对照组(P<0.05);两组患者不良反应总发生率比较,无统计学差异(P>0.05)。研究发现,临床在治疗维持性血液透析合并心力衰竭患者时,在实施常规对症治疗的基础上加用沙库巴曲缬沙坦可优化治疗效果,改善患者心肾功能,增强患者运动耐力,治疗安全性较高。

Analyze the efficacy of sacubitril and valsartan in the treatment of maintenance hemodialysis complicated with heart failure.58 patients with maintenance hemodialysis complicated with heart failure admitted to the hospital from January 2022 to December 2022 were selected as the research subjects.The patients were divided into a control group and an observation group using a random number table method,with 29 cases in each group.The control group received routine symptomatic treatment,while the observation group received treatment with sacubitril and valsartan on the basis of the control group.The treatment effects of the two groups of patients were compared.The results showed that after treatment,the electrocardiogram results of the observation group were better than those of the control group(P<0.05);After treatment,the observation group had a higher glomerular filtration rate and lower levels of blood creatinine and urea nitrogen(P<0.05);After treatment,all blood biochemical indicators in the observation group were better than those in the control group(P<0.05);After 2 weeks and 1 month of treatment,the exercise endurance of the observation group patients was better than that of the control group(P<0.05);There was no statistically significant difference in the total incidence of adverse reactions between the two groups of patients(P>0.05).Research has found that in the clinical treatment of maintenance hemodialysis patients with heart failure,adding sacubitril valsartan to routine symptomatic treatment can optimize treatment efficacy,improve patients’cardiovascular and renal function,enhance their exercise endurance,and have high treatment safety.