寒喘祖帕颗粒辅助治疗肺肾气虚证COPD患者的临床效果分析

Analysis of the effect of Hanchuan Zupa Granules as an adjuvant treatment for patients with COPD with deficiency of lung and kidney qi

目的分析肺肾气虚证慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者经寒喘祖帕颗粒辅助治疗的效果。方法选取开封市第三人民医院(祥符区第一人民医院)2023年1月至2023年12月收治的63例肺肾气虚证COPD患者为研究对象,依照治疗方案不同分为两组,对照组(31例)接受复方异丙托溴铵治疗,观察组(32例)接受寒喘祖帕颗粒辅助复方异丙托溴铵治疗。比较两组疗效、治疗前后中医证候积分、肺功能[呼气峰值流量(peak expiratory flow,PEF)、用力肺活量(forced vital capacity,FVC)、最大自主通气量(maximal voluntary ventilation,MVV)、第1 s用力呼气容积(forced expiratory volume in one second,FEV1)]、血气指标[血氧分压(partial pressure of oxygen,PaO_(2))、二氧化碳分压(Partial Pressure of Carbon Dioxide,PaCO_(2))]、炎性因子[血清白三烯B4(Leukotriene B4,LTB4)、肿瘤坏死因子-α(Tumor Necrosis Factor-α,TNF-α)、降钙素原(Procalcitonin,PCT)、半乳糖凝集素-3(galectin-3,Gal-3)]水平。结果与对照组总有效率(74.19%)比较,观察组(96.88%)较高(P<0.05);治疗后,两组中医证候积分均降低,且观察组更为明显(P<0.05);与对照组比较,观察组PaO_(2)较高,PaCO_(2)较低(P<0.05);与对照组比较,观察组PEF、FVC、MVV、FEV1均较高,血清LTB4、TNF-α、PCT、Gal-3水平均较低(P<0.05)。结论寒喘祖帕颗粒辅助治疗肺肾气虚证COPD的效果显著,能有效地恢复患者血气、肺功能,抑制血清炎性因子表达,促进临床症状改善。

Objective To analyze the effect of Hanchuan Zupa Granules as an adjuvant treatment for patients with chronic obstructive pulmonary disease(COPD)due to lung and kidney qi deficiency.Methods A total of 63 patients with COPD and deficiency of both lung and kidney qi,admitted to the Third People′s Hospital of Kaifeng(the First People′s Hospital of Xiangfu District)from January 2023 to December 2023,were included in this study.They were divided into two groups according to different treatment plans.The control group(31 cases)received compound ipratropium bromide treatment,while the observation group(32 cases)received compound ipratropium bromide treatment assisted by Hanchuan Zupa Granules.The efficacy of the two groups was compared,as well as the scores of traditional Chinese medicine symptoms,pulmonary function[peak expiratory flow(PEF),forced vital capacity(FVC),maximal voluntary ventilation(MVV),forced expiratory volume in one second(FEV1)],blood gas indices[partial pressure of oxygen(PaO_(2)),partial pressure of carbon dioxide(PaCO_(2))],and the levels of inflammatory factors[leukotriene B4(LTB4),tumor necrosis factor-α(TNF-α),procalcitonin(PCT),galectin-3(Gal-3)]before and after treatment.Results The total effective rate of the observation group(96.88%)was higher than that of the control group(74.19%)(P<0.05);after treatment,the TCM syndrome scores of both groups decreased,and the observation group showed a more significant reduction(P<0.05);after treatment,compared with the control group,PaO_(2) was higher and PaCO_(2) was lower in the observation group(P<0.05);after treatment,compared with the control group,the PEF,FVC,MVV and FEV1 of the observation group were higher,and the serum levels of LTB4,TNF-α,PCT and Gal-3 were lower(P<0.05).Conclusion The effect of Hanchuan Zupa Granules as an adjuvant treatment for COPD with deficiency of lung and kidney qi is significant,which can effectively restore patients′blood gas and lung function,inhibit the expression of serum inflammatory factors,and promote clinical symptom improvement.