中性粒细胞明胶酶相关脂质运载蛋白在克罗恩病临床诊断中的应用价值

Application value of neutrophil gelatinase associated lipocalin in clinical diagnosis of Crohn's disease

克罗恩病(CD)是一种以慢性、非特异性炎症为特征的自身免疫性肠道疾病,其病因及发病机制仍未明确。中性粒细胞明胶酶相关脂质运载蛋白(NGAL)是从中性粒细胞中分离出的一种分泌性糖蛋白,广泛参与肠道炎症反应、细胞凋亡、肿瘤进展等病理生理过程。NGAL在CD的临床诊断及活动性监测方面具有生物标志物的潜能。就NGAL在CD不同临床样本中的应用价值进行综述,以期为CD的临床诊治提供参考。

Crohn's disease(CD)is an autoimmune intestinal disease characterised by chronic and non-specific inflammation,and the exact etiology and pathogenesis are still unclear.Neutrophil gelatinase associated lipocalin(NGAL),a secreted glycoprotein and isolated from neutrophils,is widely involved in pathophysiological processes such as intestinal inflammation response,apoptosis and tumour progression.It has been found that NGAL has the potential to be a clinical biological marker in clinical diagnosis and monitoring of CD activity.Therefore,this paper reviews the application value of NGAL in different clinical samples of CD,in order to provide reference for clinical diagnosis and treatment of CD.