Electrochemical chemoselective thiocarbamylation of late-stage Tyr-containing drugs and peptides

The synthesis and modification of peptides occupy a unique position in the field of drug development,and the functionalization of amino acids is a valuable strategy as an alternative to peptide modification.Currently,the development of tyrosine(Tyr)as a target amino acid is a major challenge in the field of chemistry.Herein,we report an electrochemical radical coupling reaction of labeling tyrosine-containing active drugs and peptides with thiocarbamate derivatives for the first time.This tri-component,onepot reaction can be performed smoothly under simple,gentle,and clean electrochemical conditions and is suitable for the functionalization of various Tyr-containing drug molecular derivatives and peptides.