NLRP3炎症小体在感染性疾病中的作用研究进展

Research progress on the role of NLRP3 inflammasome in infectious diseases

核苷酸结合寡聚化结构域样受体蛋白3(Nucleotide-bindingoligomerization domain-like receptor protein 3,NLRP3)是一类存在于胞浆中的大分子蛋白复合物,作为炎症反应的核心,能够感知外源性病原体和内源性危险信号,在多种感染性疾病的发生发展中发挥重要作用。因此,本文对NLRP3炎症小体的激活机制以及NLRP3炎症小体在感染性疾病中的研究进展予以综述,旨在为感染性疾病的治疗提供新的靶点。

Nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)is a cytosolic multiprotein complex.As the core of inflammatory response,it plays a crucial role in recognizing both external pathogens and internal danger signals,influencing the onset and progression of various infectious diseases.Therefore,this review delves into the activation mechanism of the NLRP3 inflammasome and the current research advancements regarding its role in infectious diseases,aiming to provide new perspectives on the diagnosis and treatment of infectious diseases.