妊娠对肺部磨玻璃结节生长的影响

Influence of pregnancy on the growth of pulmonary ground glass nodules

目的:通过单中心回顾性队列评估妊娠与磨玻璃结节生长之间的关系。方法:回顾性分析44例因肺部磨玻璃结节行孕前和分娩后胸部CT扫描的妊娠孕妇的临床和影像学资料。根据影像学特征,将磨玻璃结节分为纯磨玻璃结节、异质性磨玻璃结节和部分实性结节。磨玻璃结节的大小定义为胸部CT扫描轴位图像中的最大直径,而观察间隔定义为孕前和分娩后胸部CT检查之间的时间间隔。当磨玻璃结节最大直径增加2 mm、固体成分增加2 mm或出现新的固体成分时,则被认为磨玻璃结节出现了生长。结果:在44例中,共检出70个磨玻璃结节,其中包括66个纯磨玻璃结节和4个异质性磨玻璃结节。其中43个磨玻璃结节直径<6 mm,22个直径6.0~7.9 mm,4个直径8.0~9.9 mm,1个直径≥10 mm。在779 d的中位观察间隔(范围为337~2795 d)内,未观察到磨玻璃结节出现生长。结论:妊娠不太可能导致肺部直径较小的纯磨玻璃结节生长。因此,育龄期女性患者如有怀孕计划,无需过度担心此类纯磨玻璃结节的生长问题。

Objective:To evaluate the relationship between pregnancy and the growth of ground glass nodules(GGNs)through a single-center retrospective cohort analysis.Methods:Clinical and radiologic data of 44 pregnant women who underwent pre-and post-pregnancy chest CT scans due to pulmonary GGNs were retrospectively reviewed.Based on imaging characteristics,the GGNs were divided into the pure GGNs(PGGNs),heterogeneous GGNs(HGGNs),and part solid nodules(PSN).The size of a GGN was determined as the maximum diameter in axial chest CT images,and the observation interval was the time between pre-and post-pregnancy chest CT scans.Growth of a GGN was defined as an increase of 2 mm in the maximum diameter,an increase of 2 mm in the solid composnent,or the appearance of new solid component.Results:Among the 44 pregnant women,70 GGNs were detected,including 66 PGGNs and 4 HGGNs.Of these,43 GGNs had a diameter of<6 mm,22 were between 6.0 and 7.9 mm,4 were between 8.0 and 9.9 mm,and 1 GGN was≥10 mm.No growth of pulmonary GGNs was observed at a median observing interval of 779 days(ranging from 337 to 2795 days).Conclusion:Pregnancy is unlikely to cause the growth of pulmonary PGGNs with a small diameter.Therefore,women of child-bearing age who plan to become pregnant need not be overly concerned about the growth of such GGNs.