二氧化硅包载对维生素C稳定性提高的研究

Study on the silicon dioxide encapsulation for the enhancement of vitamin C stability

针对化妆护肤用品中亲水活性成分维生素C(Vc)稳定性差的问题,采用二氧化硅负载Vc(Vc@SiO_(2))并通过硅烷改性(Vc@s-SiO_(2))分散在辛酸/癸酸甘油三酯(GTCC)油相体系中提升其稳定性。实验结果表明:Vc负载于二氧化硅中,包封率为68.2%、载药率为13.6%;改性后Vc@s-SiO_(2)表面疏水,接触角由33.6°增大为130.7°;分别在紫外光照射和50℃下静置时,Vc@s-SiO_(2)相较于游离Vc能相应提高11.4倍和27.7倍相对抗氧化活性。研究表明二氧化硅负载Vc并分散于GTCC中能够隔绝水和氧等不利因素,降低活性损失,提高Vc的稳定性。

To improve the stability of vitamin C(Vc)in cosmetics,Vc was coated with silica dioxide(Vc@SiO_(2)),modified by silane(Vc@s-SiO_(2))and dispersed in decanoyl/octanoyl-glycerides(GTCC)oil phase system.The experimental results show that the encapsulation rate and drug loading rate are 68.2%and 13.6%,respectively,when Vc is encapsulated into silica dioxide.After modification,the surface of Vc@s-SiO_(2) is hydrophobic and the contact angle increases from 33.6°to 130.7°.When Vc is maintained at 50℃or exposed to ultraviolet light,Vc@s-SiO_(2) exhibits an increase in antioxidant activity by 11.4 times and 27.7 times,respectively,compared to free Vc.This study reveals that silica dioxide coated Vc and dispersed in GTCC can isolate the adverse factors such as water oxygen,reduce the activity loss and improve the stability of Vc.