水化疗法在外周动脉疾病间歇性跛行患者中的应用

Application of hydration therapy in patients with intermittent claudication in peripheral artery disease

目的探讨水化疗法在外周动脉疾病间歇性跛行(IC)患者中的应用效果,为临床应用提供参考。方法采用随机对照试验方法,便利抽样法选取2023年6—9月在山西白求恩医院血管外科住院的外周动脉疾病IC患者86例为研究对象,运用随机数字表法分为对照组与干预组,每组43例。对照组行常规护理,干预组在对照组的基础上实施水化疗法,并于干预前1 d和干预6个月后评估2组患者的踝肱指数、经皮氧分压、跛行距离情况。结果每组各有42例患者完成研究,干预组男21例,女21例,年龄(61.33±8.93)岁;对照组男24例,女18例,年龄(61.36±9.01)岁。干预前1 d 2组患者的踝肱指数、经皮氧分压、跛行距离比较差异均无统计学意义(均P>0.05),干预6个月后干预组患者的经皮氧分压为(37.69±8.86)mmHg(1 mmHg=0.133 kPa),对照组为(29.69±7.79)mmHg,2组比较差异有统计学意义(t=4.40,P<0.05)。干预组患者的经皮氧分压、跛行距离干预前后的差值分别为-7.00(-13.00,-1.75)mmHg、-50.00(-100.00,0.00)m,对照组分别为0.01(-1.00,1.00)mmHg、0.01(-1.25,20.00)m,2组比较差异均有统计学意义(Z=5.59、4.33,均P<0.05)。结论水化疗法可以改善外周动脉疾病IC患者的经皮氧分压值及跛行距离,改善患者的患肢微循环。

Objective To explore the application effect of hydration therapy in patients with intermittent claudication(IC)of peripheral arterial disease,and to provide reference for clinical application.Methods A randomized controlled trial method was used to select 86 patients with IC of peripheral arterial disease who attended the Department of Vascular Surgery of Shanxi Bethune Hospital from June to September 2023 as the study subjects by convenience sampling method,and they were divided into the control group and the intervention group by using the method of randomized numerical table,each group had 43 cases.In the control group,routine care was provided,and in the intervention group,hydration therapy was implemented on the basis of the control group.Ankle-brachial index,transcutaneous partial pressure of oxygen,and claudication distance were assessed in both groups 1d before and 6 months after the intervention.Results Forty-two patients in each group completed the study,21 males and 21 females,aged(61.33±8.93)years in the intervention group;24 males and 18 females,aged(61.33±9.01)years in the control group.Compared with the ankle-brachial index,transcutaneous oxygen partial pressure and limp distance of the 2 groups 1 d before intervention,the differences were not statistically significant(all P>0.05),and 6 months after the intervention,the transcutaneous oxygen partial pressure of the patients in the intervention group was(37.69±8.86)mmHg(1 mmHg=0.133 kPa),and that of the control group was(29.69±7.79)mmHg,and the differences between the 2 groups were statistically significant(t=4.40,P<0.05).The differences in patients′transcutaneous partial pressure of oxygen and limp distance before and after intervention in the intervention group were-7.00(-13.00,-1.75)mmHg and-50.00(-100.00,0.00)m,respectively,and in the control group were 0.01(-1.00,1.00)mmHg and 0.01(-1.25,20.00)m,respectively,and the differences between the 2 groups were statistically were statistically significant(Z=5.59,4.33,both P<0.05).Conclusions Hydration therapy improves transcutaneous oxygen partial pressure values and claudication distance in patients with peripheral arterial disease IC,and improves microcirculation of the affected limbs in patients.