慢性萎缩性胃炎患者应用消化内科规范性方法治疗的效果观察

Effect Observation of Gastroenterology Normative Treatment in Patients with Chronic Atrophic Gastritis

目的:探讨对慢性萎缩性胃炎患者进行消化内科规范性方法治疗的效果。方法:2021年2月—2022年2月以泰安市妇幼保健院80例慢性萎缩性胃炎患者为对象,根据随机数字表法分为参照组与研究组,各40例。两组均给予四联疗法进行治疗,参照组为奥美拉唑、克拉霉素、甲硝唑、胶体果胶铋,研究组为雷贝拉唑、克拉霉素、阿莫西林、胶体果胶铋。对比两组治疗效果、症状消失时间、炎性因子及不良反应发生率。结果:研究组治疗总有效率高于参照组,差异具有统计学意义(P<0.05)。研究组胃痛、腹胀嗳气、反酸烧心症状消失时间低于参照组,差异均有统计学意义(P<0.05)。研究组患者治疗后肿瘤坏死因子、白细胞介素-6水平均低于参照组,差异有统计学意义(P<0.05)。研究组患者不良反应发生率与参照组比较,差异无统计学意义(P>0.05)。结论:雷贝拉唑、克拉霉素、阿莫西林、胶体果胶铋四联疗法可提高慢性萎缩性胃炎患者的治疗效果。

Objective:To investigate the effect of gastroenterology normative treatment in patients with chronic atrophic gastritis.Methods:From February 2021 to February 2022,80 patients with chronic atrophic gastritis admitted to Taian Maternity and Child Health Hospital were included as the subjects.They were divided into reference group and study group according to random number table method,with 40 cases in each group.Both groups received quadruple therapy.The reference group was treated with omeprazole,clarithromycin,metronidazole and colloidal bismuth pectin.The study group was treated with rabeprazole,clarithromycin,amoxicillin and colloidal bismuth pectin.The therapeutic effect,symptom disappearance time,inflammatory factors and incidence of adverse reactions were compared between the two groups.Results:The overall effective rate of treatment in the study group was higher than that in the reference group,and the difference was statistically significant(P<0.05).The disappearance time of stomach pain,abdominal distension and belching,acid regurgitation and heartburn symptoms in the study group was lower than that in the reference group,and the differences were statistically significant(P<0.05).The levels of tumor necrosis factor and interleukin-6 in the study group were lower than those in the reference group after treatment,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the study group and the reference group(P>0.05).Conclusion:Quadruple therapy of rabeprazole,clarithromycin,amoxicillin and colloidal bismuth pectin can improve the therapeutic effect of chronic atrophic gastritis patients.