四种肿瘤标志物检验对胃癌诊断的效果评价

Effect of Four Kinds of Tumor Markers in the Diagnosis of Gastric Cancer

目的:评价四种肿瘤标志物检验诊断胃癌的效果。方法:将2022年6月—2024年2月泰安市肿瘤防治院的胃癌患者80例设为胃癌组,另取胃部良性病变者80例设为对照组。检测两组糖类抗原19-9(CA19-9)、糖类抗原50(CA50)、糖类抗原72-4(CA72-4)、癌胚抗原(CEA)水平,并计算阳性检出率,对比单一与四项联合检测诊断阳性、阴性预测值及特异度、灵敏度。结果:胃癌组CA19-9、CA50、CA72-4、CEA水平高于对照组(P<0.05),胃癌组CA19-9、CA50、CA72-4、CEA单一检验的阳性率低于联合检验,且联合检验的灵敏度与阳性预测值高于各指标单一检验,特异度低于各指标单一检验(P<0.05)。结论:诊断胃癌选择四类肿瘤标志物检验准确率较高,可经其水平改变辅助疾病诊断,与单独检验对比,联合检验的灵敏度更高。

Objective:To evaluate the effect of four kinds of tumor markers in diagnosis of gastric cancer.Methods:Eighty patients with gastric cancer from June 2022 to February 2024 in Tai'an Cancer Prevention and Control Hospital were selected as gastric cancer group,and another eighty patients with benign stomach lesions were selected as control group.The levels of carbohydrate antigen 19-9(CA19-9),carbohydrate antigen 50(CA50),carbohydrate antigen 72-4(CA72-4)and carcinoembryonic antigen(CEA)in two groups were detected.The positive detection rate was calculated,and the positive and negative predictive value,specificity and sensitivity of single and four-item combined detection were compared.Results:The levels of CA19-9,CA50,CA72-4 and CEA in gastric cancer group were higher than those in control group(P<0.05);the positive rates of single test of CA19-9,CA50,CA72-4 and CEA in gastric cancer group were lower than those of combined test;the sensitivity and positive predictive value of the combined test were higher than that of the single test,but the specificity was lower than that of the single test(P<0.05).Conclusion:In the diagnosis of gastric cancer,the accuracy of selecting four types of tumor markers is higher,and their levels can be changed to assist disease diagnosis.Compared with the single test,the combined test has higher sensitivity.