变应性鼻炎在遗传学和表观遗传学方面的研究进展

Research progress in genetics and epigenetics of allergic rhinitis

变应性鼻炎(AR)的发病机制与遗传、环境和表观遗传因素有关。单核苷酸多态性基因分型是分子遗传学领域的一种先进技术,与患有变应性疾病人群的全基因组关联研究(GWAS)密切相关。最近的研究关注表观遗传学的作用,包括DNA甲基化、组蛋白乙酰化和微小核糖核酸(miRNA)水平的改变在AR的发病机制中的作用。本文总结了AR的遗传学和表观遗传学,包括有关先前已知和新发现的基因的功能和意义的信息。还提出了未来AR的遗传学和表观遗传学研究方向。

The pathogenesis of allergic rhinitis(AR)is related to genetic,environmental,and epigenetic factors.Single nucleotide polymorphism genotyping is an advanced technology in the field of molecular genetics,closely related to genome-wide association study(GWAS)in populations with allergic diseases.Recent research has focused on the role of epigenetics,including the role of DNA methylation,histone acetylation and changes in micro ribonucleic acid(miRNA)levels in the pathogenesis of AR.This paper summarized the genetics and epigenetics of AR,including information on the function and significance of previously known and newly discovered genes.The research direction of genetics and epigen etics of AR in the future is also put forward.