阿仑膦酸钠联合化疗对多发性骨髓瘤患者的临床效果

Clinical efficacy of alendronate sodium combined with chemotherapy in patients with multiple myeloma

目的探讨阿仑膦酸钠联合化疗对多发性骨髓瘤患者骨钙素(OC)、Ⅰ型前胶原氨基肽(PINP)和骨特异性碱性磷酸酶(BAP)的影响。方法回顾性选取2020年2月至2023年2月潜江市中心医院收治的多发性骨髓瘤患者72例,依据治疗方法分为阿仑膦酸钠联合化疗组(观察组)、单纯性常规化疗组(对照组),每组各36例。统计分析两组β胶原特殊序列(βCTx)、OC、PINP、血钙、血磷、碱性磷酸酶、BAP、免疫功能、临床疗效以及不良反应发生情况。结果治疗后,观察组患者βCTx水平、CD8^(+)均低于对照组,OC、BAP、PINP水平以及CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均高于对照组,差异有统计学意义(P<0.05),但两组患者血磷、血钙、碱性磷酸酶水平比较,差异无统计学意义(P>0.05)。观察组患者总缓解率为94.44%(34/36),高于对照组的44.44%(16/36),差异有统计学意义(P<0.05)。观察组患者不良反应总发生率为5.56%(2/36),低于对照组的27.78%(10/36),差异有统计学意义(P<0.05)。结论阿仑膦酸钠联合化疗较单纯性常规化疗更能提升多发性骨髓瘤患者OC、PINP和BAP水平及免疫功能,降低患者βCTx水平,减少患者不良反应的发生。

Objective To explore the effect of alendronate sodium combined with chemotherapy on osteocalcin(OC),typeⅠprocollagen aminopeptide(PINP)and bone specific alkaline phosphatase(BAP)in patients with multiple myeloma.Methods A total of 72 patients with multiple myeloma from Qianjiang Central Hospital from February 2020 to February 2023 were retrospectively selected and divided into two groups according to treatment methods:alendronate sodium combined with chemotherapy group(observation group)and simple conventional chemotherapy group(control group),with 36 cases in each group.Theβcollagen specific sequence(βCTx),OC,PINP,blood calcium,blood phosphorus,alkaline phosphatase,BAP,immune function,clinical efficacy and occurrence of adverse reactions were statistically analyzed in the two groups.Results After treatment,the levels ofβCTx and CD8^(+)in the observation group were lower than those in the control group,and the levels of OC,BAP,PINP,CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)were higher than those in the control group,with statistical significance(P<0.05).However,there was no statistically significant difference in the levels of blood phosphorus,blood calcium,and alkaline phosphatase between the two groups of patients(P>0.05).The total remission rate in the observation group was 94.44%(34/36)higher than that in the control group,which was 44.44%(16/36),and the difference was statistically significant(P<0.05).The total incidence of adverse reactions in the observation group was 5.56%(2/36),which was significantly lower than that in the control group(27.78%,10/36)(P<0.05).Conclusion Compared with simple routine chemotherapy,alendronate sodium combined with chemotherapy in patients with multiple myeloma can improve the levels of OC,PINP and BAP and immune function,reduce the level ofβCTx and reduce the incidence of adverse reactions.