circRNA在慢性粒细胞白血病作用的研究进展

Research progress on the role of circRNA in chronic myelogenous leukemia

环状RNA(circRNA)是一类具有共价环结构的多功能非编码RNA,它们在细胞内发挥着多种生物学功能。慢性粒细胞白血病(CML)是一种起源于造血干细胞和祖细胞的骨髓增殖性疾病。尽管目前对CML中circRNA的研究尚不全面,但已有证据显示circRNA在CML的发生发展中扮演重要角色。文章综述了circRNA在CML中的作用,特别关注其在酪氨酸激酶抑制剂(TKIs)耐药性中的作用,并探讨了circRNA在CML诊断和预后评估中的潜力,旨在为研究人员提供关于circRNA在CML作用的研究进展,为未来的研究工作提供参考。

Circular RNAs(circRNA)are a class of multifunctional non-coding RNAs with a covalently ring structure,playing a variety of biological roles within cells.Chronic myelogenous leukemia(CML)is a myeloproliferative disorder originating from hematopoietic stem cells and progenitor cells.Although the current research on circRNA in CML is not yet comprehensive,evidence has shown that circRNA plays a significant role in the onset and progression of CML.This review summarizes the involvement of circRNA in CML,particularly focusing on its contribution to tyrosine kinase inhibitors(TKIs)resistance,and discusses the potential utility of circRNA for diagnosing and assessing prognosis in CML.The objective is to provide researchers with an up-to-date overview of the role of circRNA in CML and offer references for future research endeavors.