基于“正邪理论”探讨心力衰竭心肌能量代谢及中药干预机制

Exploring myocardial energy metabolism in heart failure and the mechanism of Chinese medicine intervention based on the“theory of antipathogenic qi and pathogenic factors”

心肌能量代谢障碍是心力衰竭病变的重要特征,改善心肌能量代谢已成为防治心力衰竭的关键手段。基于病证结合、多靶点综合调控的辨治理念,中医药在改善心肌能量代谢方面显示出独特优势。心力衰竭的发生发展源于正邪相争,乃正虚邪实之证。心肌能量代谢障碍是正气亏虚的微观表现。基于“正邪理论”,以“扶正祛邪”为原则,立法选方改善心肌能量代谢,对防治心力衰竭具有重要意义。

Myocardial energy metabolism disorder is an important feature of heart failure,improving myocardial energy metabolism has become a crucial means of prevention and treatment of heart failure.Traditional Chinese medicine has shown unique advantages in terms of improving myocardial energy metabolism by virtue of its concept of syndrome differentiation and multi-target comprehensive regulation.The occurrence and development of heart failure stem from the struggle between antipathogenic qi and pathogenic factors and the syndrome type of heart failure is healthy qi deficiency and pathogenic qi excess.Dysfunction of myocardial energy metabolism can be regarded microscopically as a manifestation of healthy qi deficiency.Therefore,based on the “theory of antipathogenic qi and pathogenic factors” and the basic principle of “reinforce healthy qi to eliminate pathogenic factors”,it's of great significance for treating heart failure determining methods and selecting prescriptions to improve myocardial energy metabolism.