大黄素甲醚微囊缓释剂的制备及表征

Preparation and characterization of physcion microcapsule sustained release agent

制备一种大黄素甲醚微囊缓释剂,将大黄素甲醚制成微乳液,提高其溶解度,进一步采用原位聚合法,以密胺树脂作为囊壁,将大黄素甲醚微乳液微囊化。微乳液中大黄素甲醚的溶解度约为5 g/L,明显高于在其他溶剂中溶解度。当囊芯为微乳液(含水量30%),密胺树脂为囊壁,芯壁比(质量比)为3∶1时,所制大黄素甲醚微囊缓释剂的载药量和包封率最高,在水中14 d累积释放率为72.0%,土壤中35 d累积释放率为51.9%。该微囊缓释剂分布均匀、载药量高、释药缓慢持久,用于病害防控可减少给药次数,具有重要的实际应用价值。

To prepare physcion microcapsule sustained release agent,the physcion was made into microemulsion to increase its solubility,and in-situ polymerization was used to encapsulate physcion microemulsion with melamine-formaldehyde resin as capsule wall.The solubility of physcion in microemulsion was about 5 g/L,which was significantly higher than that in other solvents.The favorable loading capacities and encapsulation efficiencies were achieved with physcion microemulsion as core(containing 30%water),the ratio of core and wall was 3∶1.The accumulative release amounts of physcion were 72.0%and 51.9%in water(14 d)and in soil(35 d),respectively.The microcapsule sustained release agent had the advantages of uniform distribution,high drug loading,slow and long-lasting drug release,and could reduce the frequency of application,and had important practical application value.