浅谈高校动物生物安全三级实验室管理与经验交流

Discussion on the management and experience exchange of Animal Biosafety Level 3 Laboratories in universities

动物生物安全三级实验室(ABSL-3)作为国家新发再发传染病的生物安全体系基础支撑平台,为研究高致病性病原微生物的生物学特性、预防和治疗手段提供了至关重要的硬件基础。ABSL-3实验室也为高校“产学研”结合提供了重要支撑。ABSL-3实验室正常运行和科研工作顺利开展,离不开应急预案工作的精心策划和有效实施。此外,实验室合理的设计和布局也是规避和降低意外事故的关键因素。本文结合扬州大学ABSL-3建设管理实践,从应急预案准备工作入手对实验室建设布局、日常运行及污水处理、终末消毒具体措施和突发事件处置等方面的注意事项展开介绍,以期为今后操作各种病原微生物的生物安全实验室提供有益的参考。

Animal Biosafety Level 3 Laboratory(ABSL-3),as a basic support platform for the national biosafety system for emerging and re-emerging infectious diseases,provides a crucial infrastructure for the study of the biological characteristics of highly pathological pathogenic microorganisms,prevention and treatment means.The ABSL-3 laboratory also provides an important support for the university“industry-academia-research”combination.The normal operation of the ABSL-3 laboratory and the smooth development of scientific research work can not be separated from the careful planning and effective implementation of emergency preparedness work.In addition,the reasonable design and layout of the laboratory is also a key factor to avoid and reduce accidents.This paper combines Yangzhou University ABSL-3 construction and management practices,starting from the preparation of the emergency plan on the laboratory construction and layout,daily operation and sewage treatment,terminal disinfection of specific measures,and emergency disposal and other aspects of attention to be introduced,in order to provide a useful reference for the future operation of various pathogenic microorganisms biosafety laboratories.