巨噬细胞铁代谢及铁死亡的研究进展

Progress on iron metabolism and ferroptosis in macrophages

巨噬细胞具有强大的铁处理能力,在机体铁代谢调控中发挥重要作用,不同功能亚型巨噬细胞的铁代谢过程明显不同,反之铁代谢亦可以调控巨噬细胞功能状态。当巨噬细胞内铁离子超载时,可通过一系列信号通路启动细胞铁死亡程序。巨噬细胞铁死亡可加重局部炎症反应,促进代谢、感染、炎症等多种疾病的进展,因此抑制巨噬细胞铁死亡可能是重要的治疗靶点;在恶性肿瘤中,抑制M1样巨噬细胞铁死亡和促进M2样巨噬细胞铁死亡对抑制肿瘤进展具有重要意义。

Macrophages play vital roles in iron metabolism and are also modulated by iron.Macrophages are crucial to the recycling of iron and systemic iron homeostasis,and the functional heterogeneity of macrophages contributes to the different effects on iron metabolism.Conversely,iron can affect the development,function,and polarization of macrophages.Macrophages can initiate ferroptosis through a series of signaling pathways when overloaded with intracellular iron.Macrophages ferroptosis can aggravate local inflammatory reactions and promote the progression of various diseases such as metabolism,infection,and inflammation,so inhibiting macrophages ferroptosis may be an important therapeutic target.In addition,inhibiting M1-like macrophages ferroptosis and promoting M2-like macrophages ferroptosis are important in inhibiting the progression of malignant tumors.