嵌合抗原受体巨噬细胞(CAR-M)疗法在炎症相关抑郁症治疗中的应用

Application of chimeric antigen receptor macrophage(CAR-M)therapy in the treatment of inflammation-associated depression

经典的嵌合抗原受体巨噬细胞(CAR-M)发挥促炎作用实现抗肿瘤免疫,但是通过改造CAR的结构设计也可以使其有类似M2的抗炎功能,从而治疗炎症性疾病。目前靶向M1型小胶质细胞的CAR-M疗法能够有效减少神经炎症,用于治疗炎症相关抑郁症。随着关于CAR-M抗炎作用的研究不断发展,CAR-M细胞疗法为治疗炎症相关疾病提供了新的思路。

The classic Chimeric Antigen Receptor Macrophage(CAR-M)exerts pro-inflammatory effects to achieve anti-tumor immunity,but by modifying the structure design of CAR,it can acquire anti-inflammatory functions similar to M2,thereby treating inflammatory diseases.Currently,CAR-M therapy targeting M1-type microglial cells can effectively reduce neuroinflammation and be used to treat inflammation-related depression.With ongoing research on the anti-inflammatory effects of CAR-M,CAR-M cell therapy offers a new approach for treating inflammatory-related diseases.